Neuropeptides in cerebrospinal fluid and postmorten brain tissue of schizophrenics, Huntington's choreics, and normal controls

Charles Nemeroff, P. J. Manberg, E. Widerlov

Research output: Contribution to journalArticle

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Abstract

The results of measurement of neurotensin, an endogenous tridecapeptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH) in cerebrospinal fluid (CSF) of normal controls, drug-free and neuroleptic-treated schizophrenics is described. This study is of particular interest because of previous work demonstrating interactions of neurotensin (NT) with brain dopamine systems, on the one hand, and the dopamine hypothesis of schizophrenia, still generally considered the most parsimonious in view of the available data, on the other. In addition, regional brain samples from postmortem tissue of normal controls or patients who in life were diagnosed to have schizophrenia or Huntington's chorea were assayed for NT, thyrotropin-releasing hormone (TRH), and somatostatin.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalPsychopharmacology Bulletin
Volume19
Issue number3
StatePublished - Dec 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

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