The results of measurement of neurotensin, an endogenous tridecapeptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH) in cerebrospinal fluid (CSF) of normal controls, drug-free and neuroleptic-treated schizophrenics is described. This study is of particular interest because of previous work demonstrating interactions of neurotensin (NT) with brain dopamine systems, on the one hand, and the dopamine hypothesis of schizophrenia, still generally considered the most parsimonious in view of the available data, on the other. In addition, regional brain samples from postmortem tissue of normal controls or patients who in life were diagnosed to have schizophrenia or Huntington's chorea were assayed for NT, thyrotropin-releasing hormone (TRH), and somatostatin.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)