Neuropeptides in Alzheimer's disease: a postmortem study

Charles B. Nemeroff, John S. Kizer, Gavin P. Reynolds, Garth Bissette

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The concentration of 5 neuropeptides, neurotensin (NT), somatostatin (SRIF), corticotropin-releasing factor (CRF), bombesin and thyrotropin-releasing hormone (TRH) was measured in 3 cerebrocortical areas and several subcortical regions in post-mortem brains obtained from patients with histologically verified Alzheimer's disease and from controls without neurological or psychiatric disorders using sensitive and specific radioimmunoassay procedures. In Alzheimer's disease, reductions in the concentration of SRIF and CRF were observed in frontal and temporal cortex. In addition, in Alzheimer's disease, SRIF was also reduced in concentration in the hypothalamus, whereas CRF concentrations were reduced in the caudate nucleus. Neurotensin was reduced in concentration in the amygdala in Alzheimer's disease. No alterations in TRH or bombesin/gastrin-releasing peptide were found. These findings provide further evidence for the pathological involvement of certain neuropeptide-containing neurons in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalRegulatory Peptides
Volume25
Issue number1
DOIs
StatePublished - Apr 1989
Externally publishedYes

Keywords

  • Corticotropin-releasing factor
  • Neurotensin
  • Somatostatin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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