Neuropeptides, Dopamine, and Schizophrenia

CHARLES B. NEMEROFF; GARTH BISSETTE

doi:10.1111/j.1749-6632.1988.tb42113.x

Neuropeptides, Dopamine, and Schizophrenia

CHARLES B. NEMEROFF, GARTH BISSETTE

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34 Scopus citations

Abstract

In this paper, three types of evidence for the possible role of neuropeptides in the pathophysiology of schizophrenia are considered. First, studies in postmortem brain tissues and cerebrospinal fluid (CSF) have been conducted to determine whether the integrity or activity of neuropeptide-containing systems and their receptors is altered in schizophrenia. Second, studies in which peptides have been administered to schizophrenic patients to evaluate their potential therapeutic use are reviewed. Finally, the effects of peptide receptor antagonists on the symptoms of schizophrenic patients are reviewed.

Original language	English (US)
Pages (from-to)	273-291
Number of pages	19
Journal	Annals of the New York Academy of Sciences
Volume	537
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.1988.tb42113.x
State	Published - Oct 1988
Externally published	Yes

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ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Cite this

NEMEROFF, CHARLES. B., & BISSETTE, GARTH. (1988). Neuropeptides, Dopamine, and Schizophrenia. Annals of the New York Academy of Sciences, 537(1), 273-291. https://doi.org/10.1111/j.1749-6632.1988.tb42113.x

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10.1111/j.1749-6632.1988.tb42113.x