Neuropeptides, Dopamine, and Schizophrenia

CHARLES B. NEMEROFF, GARTH BISSETTE

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

In this paper, three types of evidence for the possible role of neuropeptides in the pathophysiology of schizophrenia are considered. First, studies in postmortem brain tissues and cerebrospinal fluid (CSF) have been conducted to determine whether the integrity or activity of neuropeptide-containing systems and their receptors is altered in schizophrenia. Second, studies in which peptides have been administered to schizophrenic patients to evaluate their potential therapeutic use are reviewed. Finally, the effects of peptide receptor antagonists on the symptoms of schizophrenic patients are reviewed.

Original languageEnglish (US)
Pages (from-to)273-291
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume537
Issue number1
DOIs
StatePublished - Oct 1988

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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