Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels

L. Edvinsson, E. Ekblad, R. Hakanson, Claes R Wahlestedt

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Abstract

1 The contractile effect of neuropeptide Y (NPY) was tested on isolated segments of basilar artery, central ear artery, gastro-epiploic artery and vein, and femoral artery and vein from the rabbit. At 30 nM NPY did not evoke vasoconstriction; at 300 nM NPY evoked a weak and variable response. 2 NPY greatly potentiated the response of the gastro-epiploic and femoral arteries to noradrenaline without affecting the maximum response. As tested on the gastro-epiploic artery NPY was effective at concentrations of 1 nM and higher. As tested on the femoral artery the potentiating effect of 30 nM NPY on noradrenaline-evoked contractions was apparent immediately and 30 min after the application of NPY, but not after one hour. 3 NPY (30 nM) potentiated the contractile response to noradrenaline and histamine but not to 5-hydroxytryptamine or high K+. The response to histamine was augmented in both arteries and veins, whereas the response to noradrenaline was enhanced in arteries but not in veins. NPY failed to potentiate the prostaglandin F(2α)-evoked contraction except in the gastro-epiploic vein.

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalBritish Journal of Pharmacology
Volume83
Issue number2
StatePublished - Jan 1 1984
Externally publishedYes

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Neuropeptide Y
Vasoconstrictor Agents
Blood Vessels
Rabbits
Arteries
Veins
Norepinephrine
Femoral Artery
Histamine
Basilar Artery
Femoral Vein
Prostaglandins F
Vasoconstriction
Ear
Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. / Edvinsson, L.; Ekblad, E.; Hakanson, R.; Wahlestedt, Claes R.

In: British Journal of Pharmacology, Vol. 83, No. 2, 01.01.1984, p. 519-525.

Research output: Contribution to journalArticle

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AB - 1 The contractile effect of neuropeptide Y (NPY) was tested on isolated segments of basilar artery, central ear artery, gastro-epiploic artery and vein, and femoral artery and vein from the rabbit. At 30 nM NPY did not evoke vasoconstriction; at 300 nM NPY evoked a weak and variable response. 2 NPY greatly potentiated the response of the gastro-epiploic and femoral arteries to noradrenaline without affecting the maximum response. As tested on the gastro-epiploic artery NPY was effective at concentrations of 1 nM and higher. As tested on the femoral artery the potentiating effect of 30 nM NPY on noradrenaline-evoked contractions was apparent immediately and 30 min after the application of NPY, but not after one hour. 3 NPY (30 nM) potentiated the contractile response to noradrenaline and histamine but not to 5-hydroxytryptamine or high K+. The response to histamine was augmented in both arteries and veins, whereas the response to noradrenaline was enhanced in arteries but not in veins. NPY failed to potentiate the prostaglandin F(2α)-evoked contraction except in the gastro-epiploic vein.

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