Neuropeptide Y plasma levels and immunological changes during academic stress

Luisa Guidi, Augusto Tricerri, Marcello Vangeli, Daniela Frasca, Andrea Riccardo Errani, Angela Di Giovanni, Leonardo Antico, Edoardo Menini, Vittorio Sciamanna, Nicola Magnavita, Gino Doria, Carlo Bartoloni

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Academic stress is a good model of psychological stress in humans for studying psychoneuroimmune correlations. We looked for correlations between psychological scores, immune tests and plasma levels of cortisol and neuropeptide Y (NPY). A group of medical students were evaluated at the beginning of the academic year (Baseline) and the day before an examination (Stress). They underwent evaluation by The Profile of Mood States (POMS), The Malaise Inventory, The Self Efficacy Scale and A Global Assessment of Recent Stress (GAPS). The lymphocyte subsets, the lymphocyte proliferative response and the cytokine production were also evaluated. We detected modifications of some psychological test scores between the Baseline and Stress evaluation, a significant reduction of lymphocyte proliferation, IL-2 production and percentage of the lymphocyte CD19, and an increase in plasma cortisol levels during stress. The lymphocyte proliferation negatively correlated with the POMS score as well as the percentage of CD16+ cells with NPY plasma levels. NPY levels were not different from Baseline. The emotional and mood states seem to influence immunity.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalNeuropsychobiology
Volume40
Issue number4
DOIs
StatePublished - Nov 17 1999
Externally publishedYes

Fingerprint

Neuropeptide Y
Lymphocytes
Hydrocortisone
Psychological Tests
Lymphocyte Subsets
Self Efficacy
Medical Students
Psychological Stress
Interleukin-2
Immunity
Cytokines
Psychology
Equipment and Supplies

Keywords

  • Academic stress
  • Cytokines
  • Immunology
  • Neuropeptide
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Guidi, L., Tricerri, A., Vangeli, M., Frasca, D., Errani, A. R., Di Giovanni, A., ... Bartoloni, C. (1999). Neuropeptide Y plasma levels and immunological changes during academic stress. Neuropsychobiology, 40(4), 188-195. https://doi.org/10.1159/000026618

Neuropeptide Y plasma levels and immunological changes during academic stress. / Guidi, Luisa; Tricerri, Augusto; Vangeli, Marcello; Frasca, Daniela; Errani, Andrea Riccardo; Di Giovanni, Angela; Antico, Leonardo; Menini, Edoardo; Sciamanna, Vittorio; Magnavita, Nicola; Doria, Gino; Bartoloni, Carlo.

In: Neuropsychobiology, Vol. 40, No. 4, 17.11.1999, p. 188-195.

Research output: Contribution to journalArticle

Guidi, L, Tricerri, A, Vangeli, M, Frasca, D, Errani, AR, Di Giovanni, A, Antico, L, Menini, E, Sciamanna, V, Magnavita, N, Doria, G & Bartoloni, C 1999, 'Neuropeptide Y plasma levels and immunological changes during academic stress', Neuropsychobiology, vol. 40, no. 4, pp. 188-195. https://doi.org/10.1159/000026618
Guidi L, Tricerri A, Vangeli M, Frasca D, Errani AR, Di Giovanni A et al. Neuropeptide Y plasma levels and immunological changes during academic stress. Neuropsychobiology. 1999 Nov 17;40(4):188-195. https://doi.org/10.1159/000026618
Guidi, Luisa ; Tricerri, Augusto ; Vangeli, Marcello ; Frasca, Daniela ; Errani, Andrea Riccardo ; Di Giovanni, Angela ; Antico, Leonardo ; Menini, Edoardo ; Sciamanna, Vittorio ; Magnavita, Nicola ; Doria, Gino ; Bartoloni, Carlo. / Neuropeptide Y plasma levels and immunological changes during academic stress. In: Neuropsychobiology. 1999 ; Vol. 40, No. 4. pp. 188-195.
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