Neuropeptide Y (NPY) and the central nervous system: Distribution effects and possible relationship to neurological and psychiatric disorders

Claes Wahlestedt, Rolf Ekman, Erik Widerlöv

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

1. NPY is a 36 amino acid tyrosine-rich peptide. It is one of the most abundant and widely distributed neuropeptides known today within the central nervous system with particularly high concentrations in the hypothalamus and in several limbic regions. 2. NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions. 3. NPY binding sites are widely distributed in the brain. However they do not always overlap with the distribution of NPY-like inanunoreactivity. 4. NPY is suggested to be involved in a large number of neuroendocrine functions, stress responses, circadian rhythms, central autonomic functions, eating and drinking behaviour, and sexual and motor behaviour. 5. Psychotropic drugs and neurotoxins can alter the NPY concentrations in discrete brain regions. 6. It is possible that NPY is related to various neurological and psychiatric illnesses, like Huntington's chorea, Alzheimer's disease, Parkinson's disease, eating disorders, and major depressive illness.

Original languageEnglish (US)
Pages (from-to)31-54
Number of pages24
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume13
Issue number1-2
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Central nervous system
  • neurological diseases
  • neuropeptide Y
  • psychiatric disorders

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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