Abstract
1. NPY is a 36 amino acid tyrosine-rich peptide. It is one of the most abundant and widely distributed neuropeptides known today within the central nervous system with particularly high concentrations in the hypothalamus and in several limbic regions. 2. NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions. 3. NPY binding sites are widely distributed in the brain. However they do not always overlap with the distribution of NPY-like inanunoreactivity. 4. NPY is suggested to be involved in a large number of neuroendocrine functions, stress responses, circadian rhythms, central autonomic functions, eating and drinking behaviour, and sexual and motor behaviour. 5. Psychotropic drugs and neurotoxins can alter the NPY concentrations in discrete brain regions. 6. It is possible that NPY is related to various neurological and psychiatric illnesses, like Huntington's chorea, Alzheimer's disease, Parkinson's disease, eating disorders, and major depressive illness.
| Original language | English |
|---|---|
| Pages (from-to) | 31-54 |
| Number of pages | 24 |
| Journal | Progress in Neuropsychopharmacology and Biological Psychiatry |
| Volume | 13 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
Fingerprint
Keywords
- Central nervous system
- neurological diseases
- neuropeptide Y
- psychiatric disorders
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Neuropeptide Y (NPY) and the central nervous system : Distribution effects and possible relationship to neurological and psychiatric disorders. / Wahlestedt, Claes R; Ekman, Rolf; Widerlöv, Erik.
In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 13, No. 1-2, 01.01.1989, p. 31-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropeptide Y (NPY) and the central nervous system
T2 - Distribution effects and possible relationship to neurological and psychiatric disorders
AU - Wahlestedt, Claes R
AU - Ekman, Rolf
AU - Widerlöv, Erik
PY - 1989/1/1
Y1 - 1989/1/1
N2 - 1. NPY is a 36 amino acid tyrosine-rich peptide. It is one of the most abundant and widely distributed neuropeptides known today within the central nervous system with particularly high concentrations in the hypothalamus and in several limbic regions. 2. NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions. 3. NPY binding sites are widely distributed in the brain. However they do not always overlap with the distribution of NPY-like inanunoreactivity. 4. NPY is suggested to be involved in a large number of neuroendocrine functions, stress responses, circadian rhythms, central autonomic functions, eating and drinking behaviour, and sexual and motor behaviour. 5. Psychotropic drugs and neurotoxins can alter the NPY concentrations in discrete brain regions. 6. It is possible that NPY is related to various neurological and psychiatric illnesses, like Huntington's chorea, Alzheimer's disease, Parkinson's disease, eating disorders, and major depressive illness.
AB - 1. NPY is a 36 amino acid tyrosine-rich peptide. It is one of the most abundant and widely distributed neuropeptides known today within the central nervous system with particularly high concentrations in the hypothalamus and in several limbic regions. 2. NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions. 3. NPY binding sites are widely distributed in the brain. However they do not always overlap with the distribution of NPY-like inanunoreactivity. 4. NPY is suggested to be involved in a large number of neuroendocrine functions, stress responses, circadian rhythms, central autonomic functions, eating and drinking behaviour, and sexual and motor behaviour. 5. Psychotropic drugs and neurotoxins can alter the NPY concentrations in discrete brain regions. 6. It is possible that NPY is related to various neurological and psychiatric illnesses, like Huntington's chorea, Alzheimer's disease, Parkinson's disease, eating disorders, and major depressive illness.
KW - Central nervous system
KW - neurological diseases
KW - neuropeptide Y
KW - psychiatric disorders
UR - http://www.scopus.com/inward/record.url?scp=0024601348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024601348&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(89)90003-1
DO - 10.1016/0278-5846(89)90003-1
M3 - Article
C2 - 2664885
AN - SCOPUS:0024601348
VL - 13
SP - 31
EP - 54
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 1-2
ER -