Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers

E. Ekblad, L. Edvinsson, Claes R Wahlestedt, R. Uddman, R. Håkanson, F. Sundler

Research output: Contribution to journalArticle

616 Citations (Scopus)

Abstract

Neuropeptide Y (NPY)-immunoreactive nerve fibers were numerous around arteries and few around veins. NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-β-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers. Studies on isolated blood vessels indicated that NPY is not a particularly potent contractile agent in vitro. NPY greatly enhanced the adrenergically mediated contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries. The potentiating effect of NPY on the response to electrical stimulation is probably not presynaptic since NPY affected neither the spontaneous nor the electrically evoked release of [3H]noradrenaline from perivascular sympathetic nerve fibers.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalRegulatory Peptides
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Neuropeptide Y
Nerve Fibers
Norepinephrine
Fibers
Electric Stimulation
Dopamine
Adrenergic Fibers
Sympathectomy
Blood vessels
Femoral Artery
Mixed Function Oxygenases
Histamine
Epinephrine
Blood Vessels
Veins
Arteries
Staining and Labeling
Rabbits
Enzymes

Keywords

  • co-existence
  • neuropeptide Y (NPY)
  • neuropeptides
  • noradrenaline
  • perivascular nerve fibers
  • sympathetic innervation
  • vasoconstriction

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. / Ekblad, E.; Edvinsson, L.; Wahlestedt, Claes R; Uddman, R.; Håkanson, R.; Sundler, F.

In: Regulatory Peptides, Vol. 8, No. 3, 01.01.1984, p. 225-235.

Research output: Contribution to journalArticle

Ekblad, E. ; Edvinsson, L. ; Wahlestedt, Claes R ; Uddman, R. ; Håkanson, R. ; Sundler, F. / Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. In: Regulatory Peptides. 1984 ; Vol. 8, No. 3. pp. 225-235.
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