Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively

E. Widerlöv, L. H. Lindström, C. Wahlestedt, R. Ekman

Research output: Contribution to journalArticle

229 Scopus citations


Neuropeptide Y (NPY)-like and peptide YY (PYY)-like immunoreactivities were measured in cerebrospinal fluid (CSF) from patients with major depressive disorder or schizophrenia and from healthy volunteers without physical or mental illness. NPY-like material was significantly lower (P<0.001) in CSF of patients with depressive disorders than in schizophrenic patients or healthy controls. Treatment with the antidepressant, amiflamine, a selective MAO-A inhibitor, did not alter CSF peptide concentrations. In drug-free schizophrenic patients, normal NPY but reduced PYY concentrations in CSF were observed. Treatment with neuroleptics did not affect the levels of NPY or PYY in the CSF. The finding of reduced CSF concentrations of NPY in patients with major depression and of reduced PYY concentrations in schizophrenia may reflect disturbed synthesis, turnover or degradation of the peptides. These findings suggest that the reduced concentrations of NPY or PYY in the CSF may be used as trait markers of the respective illness.

Original languageEnglish (US)
Pages (from-to)69-79
Number of pages11
JournalJournal of Psychiatric Research
Issue number1
StatePublished - 1988
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this