Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, β-endorphin and somatostatin

C. B. Nemeroff, G. Bissette, H. Akil, M. Fink

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalBritish Journal of Psychiatry
Volume158
Issue numberJAN.
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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