Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, β-endorphin and somatostatin

Charles Nemeroff, G. Bissette, H. Akil, M. Fink

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202 Citations (Scopus)

Abstract

The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalBritish Journal of Psychiatry
Volume158
Issue numberJAN.
StatePublished - Jan 1 1991
Externally publishedYes

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Endorphins
Electroconvulsive Therapy
Corticotropin-Releasing Hormone
Somatostatin
Neuropeptides
Cerebrospinal Fluid
Diagnostic and Statistical Manual of Mental Disorders
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

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