Abstract
The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.
Original language | English (US) |
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Pages (from-to) | 59-63 |
Number of pages | 5 |
Journal | British Journal of Psychiatry |
Volume | 158 |
Issue number | JAN. |
DOIs | |
State | Published - 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health