Abstract
The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | British Journal of Psychiatry |
| Volume | 158 |
| Issue number | JAN. |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
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Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, β-endorphin and somatostatin. / Nemeroff, Charles; Bissette, G.; Akil, H.; Fink, M.
In: British Journal of Psychiatry, Vol. 158, No. JAN., 01.01.1991, p. 59-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, β-endorphin and somatostatin
AU - Nemeroff, Charles
AU - Bissette, G.
AU - Akil, H.
AU - Fink, M.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.
AB - The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF of β-endorphin in depressed patients is therefore seen to be state-dependent.
UR - http://www.scopus.com/inward/record.url?scp=0026027462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026027462&partnerID=8YFLogxK
M3 - Article
C2 - 1673078
AN - SCOPUS:0026027462
VL - 158
SP - 59
EP - 63
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - JAN.
ER -