Neuropathy and ankle mobility abnormalities in patients with chronic venous disease

Elizabeth Yim, Alejandra Vivas, Andrea Maderal, Robert Kirsner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

IMPORTANCE How complications associated with chronic venous insufficiency (CVI) develop is not clear. The central source of the complications is likely a dysfunction of the calf muscle pump, which includes veins and their valves, the gastrocnemius and other lower leg and foot muscles as well as the nerves supplying the muscles, and ankle mobility limitations. The least well-studied source of complications is the relationship between range of ankle movement (ROAM), neuropathy, and the clinical severity of the disease. OBJECTIVE To study sensory neuropathic changes and ankle mobility in patients with CVI to help elucidate the pathophysiologic development of venous ulcers. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study took place from August 2011 to August 2012 at the outpatient wound clinic and the wound healing research clinic at the University of Miami Hospital. Sixty-four limbs from 42 individuals were evaluated and individually classified according to the clinical aspect of the clinical-etiology-anatomypathophysiology classification for CVI. MAIN OUTCOMES AND MEASURES Range of ankle movement was measured using goniometry, measuring active ankle combined plantarflexion and dorsiflexion and combined inversion and eversion. Peripheral neuropathy was measured subjectively through the Neuropathy Symptom Score and objectively through the Neuropathy Disability Score scales. RESULTS More patients with severe CVI had reduced plantarflexion- dorsiflexion ROAM compared with patients with mild CVI (25 [89%] vs 11 [31%]; P < .001) and reduced inversion-eversion ROAM (22 [79%] vs 4 [11%]; P < .001). Patients with worse CVI had significantly worse neuropathy with higher Neuropathy Symptom Score and Neuropathy Disability Score values compared with patients with less severe CVI. CONCLUSIONS AND RELEVANCE We found a relationship between reduced ROAM and worse neuropathy with increased severity of CVI. Management in patients with CVI should include testing for neuropathy and improving ankle mobility.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalJAMA Dermatology
Volume150
Issue number4
DOIs
StatePublished - Jan 1 2014

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Venous Insufficiency
Ankle
Chronic Disease
Muscles
Mobility Limitation
Varicose Ulcer
Peripheral Nervous System Diseases
Ambulatory Care Facilities
Wound Healing
Foot
Veins
Leg
Extremities
Cross-Sectional Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Dermatology

Cite this

Neuropathy and ankle mobility abnormalities in patients with chronic venous disease. / Yim, Elizabeth; Vivas, Alejandra; Maderal, Andrea; Kirsner, Robert.

In: JAMA Dermatology, Vol. 150, No. 4, 01.01.2014, p. 385-389.

Research output: Contribution to journalArticle

Yim, Elizabeth ; Vivas, Alejandra ; Maderal, Andrea ; Kirsner, Robert. / Neuropathy and ankle mobility abnormalities in patients with chronic venous disease. In: JAMA Dermatology. 2014 ; Vol. 150, No. 4. pp. 385-389.
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