Neuropatologia de la epilepsia refractaria en ninos

Translated title of the contribution: Neuropathology of refractory epilepsy in children

L. A. Álvarez, M. S. Duchowny, P. Jayakar, A. S. Harvey, T. J. Resnick, P. Dean, I. Yaylali, J. Bruce

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Introduction and objectives. The pathological findings in surgical material from children with refractory epilepsy has not offered yet a clear understanding of its role in this condition. The objective of this paper is to report our findings to further expand our knowledge about refractory epilepsy in children. Material and methods. Results of microscopic examination of the surgical specimen obtained from 80 children, ages 12 or younger, who had surgery for intractable epilepsy at Miami Children's Hospital between 1990 and 1996 were reviewed. Results. Examination was normal only in one. The rest revealed ectopic neurons (1), dysplastic cells with ectopic neurons (2), dyslamination with large neurons (7), dyslamination with ectopic neurons (18), dyslamination with dysplastic cells (10), gliosis without ectopic neurons (3), developmental ectodermal tumor (6), ganglioglioma (2), tumors (3), and Rasmussen encephalitis (4). Lesions were located at the temporal lobe in 34 children. Conclusions. Extratemporal lesions are more frequent than temporal ones, including hypocampal sclerosis. Ectopic neurons, the most frequent pathological findings, rather than a cause of seizure may be a marker other highly epileptogenic cortical malformations.

Translated title of the contributionNeuropathology of refractory epilepsy in children
Original languageSpanish
Pages (from-to)757-759
Number of pages3
JournalRevista de neurologia
Issue number141
StatePublished - May 1 1997


  • children
  • intractable epilepsy
  • neuropathology
  • refractory epilepsy
  • surgery

ASJC Scopus subject areas

  • Clinical Neurology


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