Neuropathologic observations in electrolyte-induced myelinosis in the rat

B. K. Kleinschmidt-DeMasters, Michael D Norenberg

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

A recent analysis of a group of patients with central pontine myelinosis (CPM) disclosed that a rapid rise in serum sodium from a hyponatremic baseline preceded the clinical onset of the disorder. To test the view that electrolyte derangements may be crucial in the pathogenesis of CPM, rats were given hypertonic saline following a three-day period of hyponatremia. Symmetrical, predominantly demyelinative lesions were found in the neocortex, claustrum, corpus striatum, external capsule, anterior commissure, hippocampus and its fimbria, thalamus, brainstem tegmentum, and superior vermis of the cerebellum. This report details the histopathology and topography of these lesions and compares them with human CPM. The findings support the view that a rapid rise in serum sodium may be responsible for the development of CPM in man.

Original languageEnglish
Pages (from-to)67-80
Number of pages14
JournalJournal of Neuropathology and Experimental Neurology
Volume41
Issue number1
StatePublished - Jan 1 1982
Externally publishedYes

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Electrolytes
Brain Fornix
Sodium
Corpus Striatum
Hyponatremia
Neocortex
Basal Ganglia
Serum
Thalamus
Cerebellum
Brain Stem
External Capsule

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Neuropathologic observations in electrolyte-induced myelinosis in the rat. / Kleinschmidt-DeMasters, B. K.; Norenberg, Michael D.

In: Journal of Neuropathology and Experimental Neurology, Vol. 41, No. 1, 01.01.1982, p. 67-80.

Research output: Contribution to journalArticle

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