TY - JOUR
T1 - Neuropathic ocular pain
T2 - An important yet underevaluated feature of dry eye
AU - Galor, A.
AU - Levitt, R. C.
AU - Felix, E. R.
AU - Martin, E. R.
AU - Sarantopoulos, C. D.
N1 - Funding Information:
This paper was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development’s Career Development Award CDA-2-024-10S (to Dr Galor), NIH Center Core Grant P30EY014801, Research to Prevent Blindness Unrestricted Grant, Department of Defense (DOD-Grant no. W81XWH-09-1-0675), and NIH NIDCR R01 DE022903 (to Drs Levitt and Martin). In addition, we note that the contents of this study do not represent the views of the Department of Veterans Affairs or the US Government.
Publisher Copyright:
© 2015 Macmillan Publishers Limited All rights reserved.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
AB - Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
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U2 - 10.1038/eye.2014.263
DO - 10.1038/eye.2014.263
M3 - Review article
C2 - 25376119
AN - SCOPUS:84924853183
VL - 29
SP - 301
EP - 312
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom
SN - 0950-222X
IS - 3
ER -