Abstract
Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 301-312 |
| Number of pages | 12 |
| Journal | Eye (Basingstoke) |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 15 2015 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Neuropathic ocular pain : An important yet underevaluated feature of dry eye. / Galor, Anat; Levitt, Roy C; Felix, Elizabeth; Martin, Eden R; Sarantopoulos, Konstantinos D.
In: Eye (Basingstoke), Vol. 29, No. 3, 15.03.2015, p. 301-312.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neuropathic ocular pain
T2 - An important yet underevaluated feature of dry eye
AU - Galor, Anat
AU - Levitt, Roy C
AU - Felix, Elizabeth
AU - Martin, Eden R
AU - Sarantopoulos, Konstantinos D.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
AB - Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
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U2 - 10.1038/eye.2014.263
DO - 10.1038/eye.2014.263
M3 - Article
VL - 29
SP - 301
EP - 312
JO - Eye (Basingstoke)
JF - Eye (Basingstoke)
SN - 0950-222X
IS - 3
ER -