Neuropathic and psychogenic itch

Gil Yosipovitch, Lena S. Samuel

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations

Abstract

Neuropathic and psychogenic itch are two entities that have not been well studied. Neuropathic itch is related to pathology located at any point along the afferent pathway of the nervous system. It could be related to damage to the peripheral nervous system, such as in postherpetic neuropathy, brachioradial pruritus, notalgia paresthetica, and in central nervous system damage as a result of spinal cord tumors and demyelinization diseases such as multiple sclerosis. It has many clinical features similar to neuropathic pain. Patients complain of itch, which coincides with burning sensation, aching, and stinging. Psychogenic itch is related to psychologic abnormalities e.g., itch in obsessive compulsive disorders, depression, and delusions of parasitosis. Although no controlled studies have been conducted for treatment of neuropathic and psychogenic itch, medications that are part of the treatment armentarium for neuropathic pain, depression, and anxiety seem to be effective.

Original languageEnglish (US)
Pages (from-to)32-41
Number of pages10
JournalDermatologic Therapy
Volume21
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Hypersensitization
  • Neuropathic pruritus
  • Neuropeptides
  • Psychogenic pruritus

ASJC Scopus subject areas

  • Dermatology

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