Neuronal intrinsic mechanisms of axon regeneration

Kai Liu, Andrea Tedeschi, Kevin Kyungsuk Park, Zhigang He

Research output: Contribution to journalArticle

260 Scopus citations

Abstract

Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

Original languageEnglish (US)
Pages (from-to)131-152
Number of pages22
JournalAnnual Review of Neuroscience
Volume34
DOIs
StatePublished - Jul 21 2011
Externally publishedYes

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Keywords

  • Axon regeneration
  • Axon transport
  • Growth cone
  • Optic nerve injury
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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