Neuronal intrinsic mechanisms of axon regeneration

Kai Liu, Andrea Tedeschi, Kevin Park, Zhigang He

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

Original languageEnglish
Pages (from-to)131-152
Number of pages22
JournalAnnual Review of Neuroscience
Volume34
DOIs
StatePublished - Jul 21 2011
Externally publishedYes

Fingerprint

Axons
Regeneration
Nervous System Trauma
Central Nervous System
Neurons
Wounds and Injuries

Keywords

  • Axon regeneration
  • Axon transport
  • Growth cone
  • Optic nerve injury
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuronal intrinsic mechanisms of axon regeneration. / Liu, Kai; Tedeschi, Andrea; Park, Kevin; He, Zhigang.

In: Annual Review of Neuroscience, Vol. 34, 21.07.2011, p. 131-152.

Research output: Contribution to journalArticle

Liu, Kai ; Tedeschi, Andrea ; Park, Kevin ; He, Zhigang. / Neuronal intrinsic mechanisms of axon regeneration. In: Annual Review of Neuroscience. 2011 ; Vol. 34. pp. 131-152.
@article{4f10f75805ce48f3a7626548278a8e82,
title = "Neuronal intrinsic mechanisms of axon regeneration",
abstract = "Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.",
keywords = "Axon regeneration, Axon transport, Growth cone, Optic nerve injury, Spinal cord injury",
author = "Kai Liu and Andrea Tedeschi and Kevin Park and Zhigang He",
year = "2011",
month = "7",
day = "21",
doi = "10.1146/annurev-neuro-061010-113723",
language = "English",
volume = "34",
pages = "131--152",
journal = "Annual Review of Neuroscience",
issn = "0147-006X",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Neuronal intrinsic mechanisms of axon regeneration

AU - Liu, Kai

AU - Tedeschi, Andrea

AU - Park, Kevin

AU - He, Zhigang

PY - 2011/7/21

Y1 - 2011/7/21

N2 - Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

AB - Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

KW - Axon regeneration

KW - Axon transport

KW - Growth cone

KW - Optic nerve injury

KW - Spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=79959897174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959897174&partnerID=8YFLogxK

U2 - 10.1146/annurev-neuro-061010-113723

DO - 10.1146/annurev-neuro-061010-113723

M3 - Article

VL - 34

SP - 131

EP - 152

JO - Annual Review of Neuroscience

JF - Annual Review of Neuroscience

SN - 0147-006X

ER -