Neuronal histamine in the gut wall releasable by gastrin and cholecystokinin

R. Hákanson, C. Wahlestedt, L. Westlin, S. Vallgren, F. Sundler

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Histamine accumulated in the ligated vagus nerve of the rat, both above and below the ligature; maximum accumulation was after 4 h. The finding is suggestive of axonal flow. Further evidence for histamine in peripheral nerves was obtained in experiments showing that the guinea-pig gut wall could be labelled with [3H]histamine. The experiments were carried out with isolated strips of stomach wall and taenia coli. Electrical stimulation released [3H]histamine from these specimens. The release could be blocked by Ca2+-free medium or by tetrodotoxin. The release was unaffected by vagal denervation or chemical sympathectomy (6-hydroxydopamine) but prevented by reserpinization. Gastrin-17 and cholecystokinin-39 released radioactivity by a tetrodotoxin-sensitive mechanism. The possible existence of a gastrin/cholecystokinin-sensitive neuronal pool of histamine in the gut wall offers a new perspective on the postulated role of histamine as a physiological stimulant of gastric acid secretion and might explain why H2-receptor antagonists block gastrin-stimulated acid secretion.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalNeuroscience Letters
Issue number3
StatePublished - Dec 11 1983
Externally publishedYes


  • cholecystokinin
  • gastrin
  • histamine
  • histamine release
  • histaminergic neurones
  • neuronal histamine

ASJC Scopus subject areas

  • Neuroscience(all)


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