Abstract
Histamine accumulated in the ligated vagus nerve of the rat, both above and below the ligature; maximum accumulation was after 4 h. The finding is suggestive of axonal flow. Further evidence for histamine in peripheral nerves was obtained in experiments showing that the guinea-pig gut wall could be labelled with [3H]histamine. The experiments were carried out with isolated strips of stomach wall and taenia coli. Electrical stimulation released [3H]histamine from these specimens. The release could be blocked by Ca2+-free medium or by tetrodotoxin. The release was unaffected by vagal denervation or chemical sympathectomy (6-hydroxydopamine) but prevented by reserpinization. Gastrin-17 and cholecystokinin-39 released radioactivity by a tetrodotoxin-sensitive mechanism. The possible existence of a gastrin/cholecystokinin-sensitive neuronal pool of histamine in the gut wall offers a new perspective on the postulated role of histamine as a physiological stimulant of gastric acid secretion and might explain why H2-receptor antagonists block gastrin-stimulated acid secretion.
Original language | English (US) |
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Pages (from-to) | 305-310 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 42 |
Issue number | 3 |
DOIs | |
State | Published - Dec 11 1983 |
Externally published | Yes |
Keywords
- cholecystokinin
- gastrin
- histamine
- histamine release
- histaminergic neurones
- neuronal histamine
ASJC Scopus subject areas
- Neuroscience(all)