Neuronal chemotaxis: Chick dorsal-root axons turn toward high concentrations of nerve growth factor

R. W. Gundersen, J. N. Barrett

Research output: Contribution to journalArticle

380 Scopus citations

Abstract

Micropipettes containing 2 to 50 biological unit of β nerve growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.

Original languageEnglish (US)
Pages (from-to)1079-1080
Number of pages2
JournalScience
Volume206
Issue number4422
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

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