Neuronal chemotaxis: Chick dorsal-root axons turn toward high concentrations of nerve growth factor

R. W. Gundersen, John Barrett

Research output: Contribution to journalArticle

372 Citations (Scopus)

Abstract

Micropipettes containing 2 to 50 biological unit of β nerve growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.

Original languageEnglish
Pages (from-to)1079-1080
Number of pages2
JournalScience
Volume206
Issue number4422
StatePublished - Dec 1 1979

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Spinal Nerve Roots
Nerve Growth Factor
Chemotaxis
Axons
Spinal Ganglia
Neurons
Growth

ASJC Scopus subject areas

  • General

Cite this

Neuronal chemotaxis : Chick dorsal-root axons turn toward high concentrations of nerve growth factor. / Gundersen, R. W.; Barrett, John.

In: Science, Vol. 206, No. 4422, 01.12.1979, p. 1079-1080.

Research output: Contribution to journalArticle

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