Neuron-Intrinsic Inhibitors of Axon Regeneration: PTEN and SOCS3

Xueting Luo, Kevin Park

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Our understanding of how axon regeneration is controlled in both the peripheral and central nervous systems remains fragmentary. Research into the regenerative capacity of adult neurons has elucidated PTEN and SOCS3 as distinctive but complementary arms of the regenerative program. These molecules act as negative regulators of major signaling pathways and impact the processes occurring in the cell body, such as protein translation and transcription, and in the axons, such as cytoskeleton assembly. In this review, we summarize the role of PTEN and SOCS3 in limiting axon regeneration and discuss the molecular and cellular mechanisms underlying their growth-inhibitory effects.

Original languageEnglish
Pages (from-to)141-173
Number of pages33
JournalInternational Review of Neurobiology
Volume105
DOIs
StatePublished - Dec 1 2012

Keywords

  • Axon
  • Growth and axotomy
  • PTEN
  • Regeneration
  • SOCS3

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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