Neuron-Intrinsic Inhibitors of Axon Regeneration: PTEN and SOCS3

Xueting Luo, Kevin Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Our understanding of how axon regeneration is controlled in both the peripheral and central nervous systems remains fragmentary. Research into the regenerative capacity of adult neurons has elucidated PTEN and SOCS3 as distinctive but complementary arms of the regenerative program. These molecules act as negative regulators of major signaling pathways and impact the processes occurring in the cell body, such as protein translation and transcription, and in the axons, such as cytoskeleton assembly. In this review, we summarize the role of PTEN and SOCS3 in limiting axon regeneration and discuss the molecular and cellular mechanisms underlying their growth-inhibitory effects.

Original languageEnglish
Pages (from-to)141-173
Number of pages33
JournalInternational Review of Neurobiology
Volume105
DOIs
StatePublished - Dec 1 2012

Fingerprint

Axons
Regeneration
Neurons
Peripheral Nervous System
Protein Biosynthesis
Cytoskeleton
Central Nervous System
Growth
Research
Cell Body

Keywords

  • Axon
  • Growth and axotomy
  • PTEN
  • Regeneration
  • SOCS3

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Neuron-Intrinsic Inhibitors of Axon Regeneration : PTEN and SOCS3. / Luo, Xueting; Park, Kevin.

In: International Review of Neurobiology, Vol. 105, 01.12.2012, p. 141-173.

Research output: Contribution to journalArticle

@article{0db0adcfe9064822bc395515846ce4e9,
title = "Neuron-Intrinsic Inhibitors of Axon Regeneration: PTEN and SOCS3",
abstract = "Our understanding of how axon regeneration is controlled in both the peripheral and central nervous systems remains fragmentary. Research into the regenerative capacity of adult neurons has elucidated PTEN and SOCS3 as distinctive but complementary arms of the regenerative program. These molecules act as negative regulators of major signaling pathways and impact the processes occurring in the cell body, such as protein translation and transcription, and in the axons, such as cytoskeleton assembly. In this review, we summarize the role of PTEN and SOCS3 in limiting axon regeneration and discuss the molecular and cellular mechanisms underlying their growth-inhibitory effects.",
keywords = "Axon, Growth and axotomy, PTEN, Regeneration, SOCS3",
author = "Xueting Luo and Kevin Park",
year = "2012",
month = "12",
day = "1",
doi = "10.1016/B978-0-12-398309-1.00008-1",
language = "English",
volume = "105",
pages = "141--173",
journal = "International Review of Neurobiology",
issn = "0074-7742",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Neuron-Intrinsic Inhibitors of Axon Regeneration

T2 - PTEN and SOCS3

AU - Luo, Xueting

AU - Park, Kevin

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Our understanding of how axon regeneration is controlled in both the peripheral and central nervous systems remains fragmentary. Research into the regenerative capacity of adult neurons has elucidated PTEN and SOCS3 as distinctive but complementary arms of the regenerative program. These molecules act as negative regulators of major signaling pathways and impact the processes occurring in the cell body, such as protein translation and transcription, and in the axons, such as cytoskeleton assembly. In this review, we summarize the role of PTEN and SOCS3 in limiting axon regeneration and discuss the molecular and cellular mechanisms underlying their growth-inhibitory effects.

AB - Our understanding of how axon regeneration is controlled in both the peripheral and central nervous systems remains fragmentary. Research into the regenerative capacity of adult neurons has elucidated PTEN and SOCS3 as distinctive but complementary arms of the regenerative program. These molecules act as negative regulators of major signaling pathways and impact the processes occurring in the cell body, such as protein translation and transcription, and in the axons, such as cytoskeleton assembly. In this review, we summarize the role of PTEN and SOCS3 in limiting axon regeneration and discuss the molecular and cellular mechanisms underlying their growth-inhibitory effects.

KW - Axon

KW - Growth and axotomy

KW - PTEN

KW - Regeneration

KW - SOCS3

UR - http://www.scopus.com/inward/record.url?scp=84872395057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872395057&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-398309-1.00008-1

DO - 10.1016/B978-0-12-398309-1.00008-1

M3 - Article

C2 - 23206599

AN - SCOPUS:84872395057

VL - 105

SP - 141

EP - 173

JO - International Review of Neurobiology

JF - International Review of Neurobiology

SN - 0074-7742

ER -