Neuromuscular Junction (NMJ): Presynaptic Short-Term Plasticity of Neuromuscular Transmission

A. M. Holohean, Karl Magleby

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The amount of transmitter released from a synapse by each nerve impulse typically varies as a function of previous synaptic activity. These stimulation-induced changes in transmitter release produce changes in postsynaptic potential amplitudes and synaptic efficacy and occur at most central and peripheral chemical synapses. Such changes in synaptic efficacy are also referred to as use-dependent or historical effects, since the previous use (history) of the synapse determines its current efficacy. Depending on the particular synapse, stimulation pattern, and levels of transmitter release, repetitive stimulation can increase or decrease synaptic efficacy, and the time course of these effects can range from milliseconds to days. This article focuses on short-term changes in synaptic efficacy which last from milliseconds to tens of minutes.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages629-634
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Dec 1 2010

Fingerprint

Neuromuscular Junction
Synapses
Synaptic Potentials
Action Potentials
History

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuromuscular Junction (NMJ) : Presynaptic Short-Term Plasticity of Neuromuscular Transmission. / Holohean, A. M.; Magleby, Karl.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 629-634.

Research output: Chapter in Book/Report/Conference proceedingChapter

Holohean, A. M. ; Magleby, Karl. / Neuromuscular Junction (NMJ) : Presynaptic Short-Term Plasticity of Neuromuscular Transmission. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 629-634
@inbook{a0f17ac0902c4b80959822202899a720,
title = "Neuromuscular Junction (NMJ): Presynaptic Short-Term Plasticity of Neuromuscular Transmission",
abstract = "The amount of transmitter released from a synapse by each nerve impulse typically varies as a function of previous synaptic activity. These stimulation-induced changes in transmitter release produce changes in postsynaptic potential amplitudes and synaptic efficacy and occur at most central and peripheral chemical synapses. Such changes in synaptic efficacy are also referred to as use-dependent or historical effects, since the previous use (history) of the synapse determines its current efficacy. Depending on the particular synapse, stimulation pattern, and levels of transmitter release, repetitive stimulation can increase or decrease synaptic efficacy, and the time course of these effects can range from milliseconds to days. This article focuses on short-term changes in synaptic efficacy which last from milliseconds to tens of minutes.",
author = "Holohean, {A. M.} and Karl Magleby",
year = "2010",
month = "12",
day = "1",
doi = "10.1016/B978-008045046-9.01280-8",
language = "English",
isbn = "9780080450469",
pages = "629--634",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Neuromuscular Junction (NMJ)

T2 - Presynaptic Short-Term Plasticity of Neuromuscular Transmission

AU - Holohean, A. M.

AU - Magleby, Karl

PY - 2010/12/1

Y1 - 2010/12/1

N2 - The amount of transmitter released from a synapse by each nerve impulse typically varies as a function of previous synaptic activity. These stimulation-induced changes in transmitter release produce changes in postsynaptic potential amplitudes and synaptic efficacy and occur at most central and peripheral chemical synapses. Such changes in synaptic efficacy are also referred to as use-dependent or historical effects, since the previous use (history) of the synapse determines its current efficacy. Depending on the particular synapse, stimulation pattern, and levels of transmitter release, repetitive stimulation can increase or decrease synaptic efficacy, and the time course of these effects can range from milliseconds to days. This article focuses on short-term changes in synaptic efficacy which last from milliseconds to tens of minutes.

AB - The amount of transmitter released from a synapse by each nerve impulse typically varies as a function of previous synaptic activity. These stimulation-induced changes in transmitter release produce changes in postsynaptic potential amplitudes and synaptic efficacy and occur at most central and peripheral chemical synapses. Such changes in synaptic efficacy are also referred to as use-dependent or historical effects, since the previous use (history) of the synapse determines its current efficacy. Depending on the particular synapse, stimulation pattern, and levels of transmitter release, repetitive stimulation can increase or decrease synaptic efficacy, and the time course of these effects can range from milliseconds to days. This article focuses on short-term changes in synaptic efficacy which last from milliseconds to tens of minutes.

UR - http://www.scopus.com/inward/record.url?scp=84882862386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882862386&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.01280-8

DO - 10.1016/B978-008045046-9.01280-8

M3 - Chapter

AN - SCOPUS:84882862386

SN - 9780080450469

SP - 629

EP - 634

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -