Neuromuscular development in Drosophila

Insights from single neurons and single genes

Haig Keshishian, Akira Chiba

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

How a neuron finds its synoptic target is one of the key questions of developmental neurobiology. It is a problem that must, at least in part, be explained in molecular terms. In light of this, several groups have recently examined the synapses that are made between individual motoneurons and muscle fibers in the embryos and larvae of the fruit fly Drosophila melanogaster. The work combines the traditions of small system neurobiology, which is founded on the analysis of singly identified cells, with those of developmental genetics. An important insight emerging from the work is that many of the familiar features of vertebrate synaptogenesis occur in Drosophila, where a rich array of genetic and molecular methods may be readily applied.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalTrends in Neurosciences
Volume16
Issue number7
StatePublished - Dec 1 1993
Externally publishedYes

Fingerprint

Neurobiology
Drosophila
Neurons
Motor Neurons
Drosophila melanogaster
Diptera
Synapses
Genes
Larva
Vertebrates
Molecular Biology
Fruit
Embryonic Structures
Muscles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuromuscular development in Drosophila : Insights from single neurons and single genes. / Keshishian, Haig; Chiba, Akira.

In: Trends in Neurosciences, Vol. 16, No. 7, 01.12.1993, p. 278-283.

Research output: Contribution to journalArticle

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