Neuromonitoring with microdialysis in severe traumatic brain injury patients.

Jose J. Sanchez, Carlos J. Bidot, Kristine H O'Phelan, Shyam Gajavelli, Shoji Yokobori, Stephen Olvey, Jonathan Jagid, Jose Alberto Garcia, Zsuzsanna Nemeth, Ross Bullock

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Neuromonitoring with microdialysis has the potential for early detection of metabolic derangements associated with TBI. 1,260 microdialysis samples from 12 TBI patients were analyzed for glucose, -lactate, pyruvate, lactate/pyruvate ratio (LPR), and lactate/glucose ratio (LGR). Analytes were correlated with the Glasgow Coma Scale (GCS) before surgery and with the Glasgow Outcome Scale (GOS) at the time of discharge. The patients were divided into two groups for GCS: 3-6 and 7-9, and for GOS 1-3 and 4-5. Chi-squared test was performed for correlations. Glucose, lactate levels, and LGR were high in TBI patients with GCS 3-6 (p < 0.0001). Pyruvate level was lower in patients with GCS 7-9 (p < 0.001). LPR was higher in patients with GCS 3-6 (p < 0.05). High glucose, lactate level (p < 0.001), and LPR (p < 0.01) was observed in patients with GOS 1-3. Pyruvate level was low in patients with GOS 1-3 (p < 0.001). LGR was higher in patient with better outcome (GOS 4-5). After craniotomy extracellular glucose and lactate were good "biomarkers" of cerebral damage in TBI patients. We consider that high extracellular lactate and low glucose is an indicator of severe neurological damage and poor outcome, because of impaired brain metabolism.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalActa neurochirurgica. Supplement
Volume118
StatePublished - Aug 15 2013
Externally publishedYes

Fingerprint

brain damage
lactates
Microdialysis
Glucose
Lactic Acid
Brain
pyruvates
glucose
Glasgow Outcome Scale
Glasgow Coma Scale
Pyruvic Acid
coma
Traumatic Brain Injury
Biomarkers
damage
Metabolism
Surgery
Craniotomy
biomarkers
metabolism

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Sanchez, J. J., Bidot, C. J., O'Phelan, K. H., Gajavelli, S., Yokobori, S., Olvey, S., ... Bullock, R. (2013). Neuromonitoring with microdialysis in severe traumatic brain injury patients. Acta neurochirurgica. Supplement, 118, 223-227.

Neuromonitoring with microdialysis in severe traumatic brain injury patients. / Sanchez, Jose J.; Bidot, Carlos J.; O'Phelan, Kristine H; Gajavelli, Shyam; Yokobori, Shoji; Olvey, Stephen; Jagid, Jonathan; Garcia, Jose Alberto; Nemeth, Zsuzsanna; Bullock, Ross.

In: Acta neurochirurgica. Supplement, Vol. 118, 15.08.2013, p. 223-227.

Research output: Contribution to journalArticle

Sanchez, JJ, Bidot, CJ, O'Phelan, KH, Gajavelli, S, Yokobori, S, Olvey, S, Jagid, J, Garcia, JA, Nemeth, Z & Bullock, R 2013, 'Neuromonitoring with microdialysis in severe traumatic brain injury patients.', Acta neurochirurgica. Supplement, vol. 118, pp. 223-227.
Sanchez JJ, Bidot CJ, O'Phelan KH, Gajavelli S, Yokobori S, Olvey S et al. Neuromonitoring with microdialysis in severe traumatic brain injury patients. Acta neurochirurgica. Supplement. 2013 Aug 15;118:223-227.
Sanchez, Jose J. ; Bidot, Carlos J. ; O'Phelan, Kristine H ; Gajavelli, Shyam ; Yokobori, Shoji ; Olvey, Stephen ; Jagid, Jonathan ; Garcia, Jose Alberto ; Nemeth, Zsuzsanna ; Bullock, Ross. / Neuromonitoring with microdialysis in severe traumatic brain injury patients. In: Acta neurochirurgica. Supplement. 2013 ; Vol. 118. pp. 223-227.
@article{868a06564c374415a490b0e4270f1edc,
title = "Neuromonitoring with microdialysis in severe traumatic brain injury patients.",
abstract = "Neuromonitoring with microdialysis has the potential for early detection of metabolic derangements associated with TBI. 1,260 microdialysis samples from 12 TBI patients were analyzed for glucose, -lactate, pyruvate, lactate/pyruvate ratio (LPR), and lactate/glucose ratio (LGR). Analytes were correlated with the Glasgow Coma Scale (GCS) before surgery and with the Glasgow Outcome Scale (GOS) at the time of discharge. The patients were divided into two groups for GCS: 3-6 and 7-9, and for GOS 1-3 and 4-5. Chi-squared test was performed for correlations. Glucose, lactate levels, and LGR were high in TBI patients with GCS 3-6 (p < 0.0001). Pyruvate level was lower in patients with GCS 7-9 (p < 0.001). LPR was higher in patients with GCS 3-6 (p < 0.05). High glucose, lactate level (p < 0.001), and LPR (p < 0.01) was observed in patients with GOS 1-3. Pyruvate level was low in patients with GOS 1-3 (p < 0.001). LGR was higher in patient with better outcome (GOS 4-5). After craniotomy extracellular glucose and lactate were good {"}biomarkers{"} of cerebral damage in TBI patients. We consider that high extracellular lactate and low glucose is an indicator of severe neurological damage and poor outcome, because of impaired brain metabolism.",
author = "Sanchez, {Jose J.} and Bidot, {Carlos J.} and O'Phelan, {Kristine H} and Shyam Gajavelli and Shoji Yokobori and Stephen Olvey and Jonathan Jagid and Garcia, {Jose Alberto} and Zsuzsanna Nemeth and Ross Bullock",
year = "2013",
month = "8",
day = "15",
language = "English",
volume = "118",
pages = "223--227",
journal = "Scientific Computing and Instrumentation",
issn = "1078-8956",
publisher = "Springer Wien",

}

TY - JOUR

T1 - Neuromonitoring with microdialysis in severe traumatic brain injury patients.

AU - Sanchez, Jose J.

AU - Bidot, Carlos J.

AU - O'Phelan, Kristine H

AU - Gajavelli, Shyam

AU - Yokobori, Shoji

AU - Olvey, Stephen

AU - Jagid, Jonathan

AU - Garcia, Jose Alberto

AU - Nemeth, Zsuzsanna

AU - Bullock, Ross

PY - 2013/8/15

Y1 - 2013/8/15

N2 - Neuromonitoring with microdialysis has the potential for early detection of metabolic derangements associated with TBI. 1,260 microdialysis samples from 12 TBI patients were analyzed for glucose, -lactate, pyruvate, lactate/pyruvate ratio (LPR), and lactate/glucose ratio (LGR). Analytes were correlated with the Glasgow Coma Scale (GCS) before surgery and with the Glasgow Outcome Scale (GOS) at the time of discharge. The patients were divided into two groups for GCS: 3-6 and 7-9, and for GOS 1-3 and 4-5. Chi-squared test was performed for correlations. Glucose, lactate levels, and LGR were high in TBI patients with GCS 3-6 (p < 0.0001). Pyruvate level was lower in patients with GCS 7-9 (p < 0.001). LPR was higher in patients with GCS 3-6 (p < 0.05). High glucose, lactate level (p < 0.001), and LPR (p < 0.01) was observed in patients with GOS 1-3. Pyruvate level was low in patients with GOS 1-3 (p < 0.001). LGR was higher in patient with better outcome (GOS 4-5). After craniotomy extracellular glucose and lactate were good "biomarkers" of cerebral damage in TBI patients. We consider that high extracellular lactate and low glucose is an indicator of severe neurological damage and poor outcome, because of impaired brain metabolism.

AB - Neuromonitoring with microdialysis has the potential for early detection of metabolic derangements associated with TBI. 1,260 microdialysis samples from 12 TBI patients were analyzed for glucose, -lactate, pyruvate, lactate/pyruvate ratio (LPR), and lactate/glucose ratio (LGR). Analytes were correlated with the Glasgow Coma Scale (GCS) before surgery and with the Glasgow Outcome Scale (GOS) at the time of discharge. The patients were divided into two groups for GCS: 3-6 and 7-9, and for GOS 1-3 and 4-5. Chi-squared test was performed for correlations. Glucose, lactate levels, and LGR were high in TBI patients with GCS 3-6 (p < 0.0001). Pyruvate level was lower in patients with GCS 7-9 (p < 0.001). LPR was higher in patients with GCS 3-6 (p < 0.05). High glucose, lactate level (p < 0.001), and LPR (p < 0.01) was observed in patients with GOS 1-3. Pyruvate level was low in patients with GOS 1-3 (p < 0.001). LGR was higher in patient with better outcome (GOS 4-5). After craniotomy extracellular glucose and lactate were good "biomarkers" of cerebral damage in TBI patients. We consider that high extracellular lactate and low glucose is an indicator of severe neurological damage and poor outcome, because of impaired brain metabolism.

UR - http://www.scopus.com/inward/record.url?scp=84881334140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881334140&partnerID=8YFLogxK

M3 - Article

C2 - 23564137

AN - SCOPUS:84881334140

VL - 118

SP - 223

EP - 227

JO - Scientific Computing and Instrumentation

JF - Scientific Computing and Instrumentation

SN - 1078-8956

ER -