Neuromonitoring of cochlea and auditory nerve with multiple extracted parameters during induced hypoxia and nerve manipulation

Jorge Bohorquez, Ozcan Ozdamar, Krzysztof Morawski, Fred F Telischi, Rafael E. Delgado, Erdem Yavuz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A system capable of comprehensive and detailed monitoring of the cochlea and the auditory nerve during intraoperative surgery was developed. The cochlear blood flow (CBF) and the electrocochleogram (ECochGm) were recorded at the round window (RW) niche using a specially designed otic probe. The ECochGm was further processed to obtain cochlear microphonics (CM) and compound action potentials (CAP). The amplitude and phase of the CM were used to quantify the activity of outer hair cells (OHC); CAP amplitude and latency were used to describe the auditory nerve and the synaptic activity of the inner hair cells (IHC). In addition, concurrent monitoring with a second electrophysiological channel was achieved by recording compound nerve action potential (CNAP) obtained directly from the auditory nerve. Stimulation paradigms, instrumentation and signal processing methods were developed to extract and differentiate the activity of the OHC and the IHC in response to three different frequencies. Narrow band acoustical stimuli elicited CM signals indicating mainly nonlinear operation of the mechano-electrical transduction of the OHCs. Special envelope detectors were developed and applied to the ECochGm to extract the CM fundamental component and its harmonics in real time. The system was extensively validated in experimental animal surgeries by performing nerve compressions and manipulations.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Neural Engineering
Volume2
Issue number2
DOIs
StatePublished - Jun 1 2005

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Microphonism
Cochlear Nerve
Cochlea
Outer Auditory Hair Cells
Inner Auditory Hair Cells
Cells
Surgery
Action Potentials
Monitoring
Signal processing
Animals
Blood
Detectors
Ear
Hypoxia

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Neuroscience (miscellaneous)

Cite this

Neuromonitoring of cochlea and auditory nerve with multiple extracted parameters during induced hypoxia and nerve manipulation. / Bohorquez, Jorge; Ozdamar, Ozcan; Morawski, Krzysztof; Telischi, Fred F; Delgado, Rafael E.; Yavuz, Erdem.

In: Journal of Neural Engineering, Vol. 2, No. 2, 01.06.2005, p. 1-10.

Research output: Contribution to journalArticle

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