Neuromodulation of consciousness disorders

Ana Ciurea, Jean Ciurea, Ioan Opris

Research output: Chapter in Book/Report/Conference proceedingChapter


Some patients may develop an altered state of consciousness (coma, vegetative state, minimal consciousness state) following traumatic and other brain injuries. While the cause of their altered consciousness may be well documented in most cases, the precise underlying mechanisms mediating the altered consciousness and its treatment are yet to be discovered. Several hypotheses have been put forward on how the level of consciousness can be improved; all are based on the principle that an injured brain needs to reconnect its disrupted areas. To address this need, several neuromodulation therapies (using invasive and noninvasive stimulation) may serve this purpose. Invasive therapies use chronic electrodes for stimulation, while non-invasive therapies employ transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and somato-sensitive stimulation (SSS). The purpose of this chapter is to critically analyze the progress of these therapeutic methods and to review what is still needed to improve the impaired conscious states.

Original languageEnglish (US)
Title of host publicationElectroceuticals
Subtitle of host publicationAdvances in Electrostimulation Therapies
PublisherSpringer International Publishing
Number of pages30
ISBN (Electronic)9783319286129
ISBN (Print)9783319286105
StatePublished - Jan 31 2017


  • Awareness
  • Consciousness
  • Disturbance
  • Neuromodulation
  • TMS
  • Therapy
  • Vegetative state
  • tDCS

ASJC Scopus subject areas

  • Medicine(all)


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