Neuromodulation for Gait Disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Both the clinical success of deep brain stimulation for Parkinson’s disease and the discovery that epidural spinal cord stimulation can restore volitional movement in patients with chronic motor-complete spinal cord injury were paradigm shifting milestones that sparked the field of neuromodulation. The rapid expansion of neuromodulatory approaches and targets being researched today underlies the high hopes and expectations of the neuroscience community. Here, we provide an overview of the neurophysiological basis of gait, the pathophysiology of some common gait disorders, and review the most promising neuromodulatory strategies being investigated to augment one of our most fundamental daily activities—walking.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
PublisherSpringer Nature
Pages485-520
Number of pages36
DOIs
StatePublished - 2021

Publication series

NameContemporary Clinical Neuroscience
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341

Keywords

  • Cuneiform nucleus
  • Deep brain stimulation
  • Epidural stimulation
  • Gait
  • Mesencephalic locomotor region
  • Neuromodulation
  • Pedunculopontine nucleus

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Sensory Systems
  • Clinical Neurology

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