Neurological syndromes complicating AIDS.

B. D. Jordan, B. A. Navia, Carol Petito, E. S. Cho, R. W. Price

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

This article presents a preliminary analysis of 118 acquired immunodeficiency syndrome (AIDS) patients with neurologic disease. 86% of patients in this series were homosexual, and the AIDS diagnosis was made on the basis of opportunistic infection in almost 50% and of Kaposi's sarcoma with or without opportunistic infection in 38%. Central nervous system (CNS) infections (e.g., subacute encephalitis, toxoplasmosis, primary CNS lymphoma) were the most common group of complications, and autopsy findings indicated that 87% of patients eventually developed CNS complications. Subacute encephalitis was found alone or with other pathology in over 2/3 of autopsied brains. Principal neuropathologic changes in AIDS include the presence of scattered glial nodules, especially in gray matter. To define the clinical features of the glial nodule subacute encephalitis, the clinical features of 18 patients exhibiting these changes at postmortem examination were further analyzed. With the exception of seizures, clinical manifestations were nonfocal, correlating with the diffuse distribution of the microscopic pathology. CNS symptoms most commonly followed the diagnosis of AIDS by 2-9 months, and 11 of these 18 patients died within 6 months of onset of CNS dysfunction. The electroencephalogram (EEG) was abnormal in 100% of patients tested, while computerized tomographic (CT) scans were abnormal in 70%, with cortical atrophy being the most common finding. The cerebral spinal fluid (CSF) was abnormal in 67%. Early complaints were difficulty in concentration or memory loss which progressed in some to severe global dementia or coma. Neither the etiology nor the pathogenesis of subacute encephalitis have been established, although cytomegalovirus is regarded as a prime etiologic candidate.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalFrontiers of radiation therapy and oncology
Volume19
StatePublished - Jan 1 1985
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Encephalitis
Central Nervous System
Opportunistic Infections
Neuroglia
Autopsy
Cerebral Toxoplasmosis
Wiskott-Aldrich Syndrome
Pathology
Central Nervous System Infections
Kaposi's Sarcoma
Memory Disorders
Coma
Nervous System Diseases
Cytomegalovirus
Atrophy
Dementia
Electroencephalography
Lymphoma
Seizures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jordan, B. D., Navia, B. A., Petito, C., Cho, E. S., & Price, R. W. (1985). Neurological syndromes complicating AIDS. Frontiers of radiation therapy and oncology, 19, 82-87.

Neurological syndromes complicating AIDS. / Jordan, B. D.; Navia, B. A.; Petito, Carol; Cho, E. S.; Price, R. W.

In: Frontiers of radiation therapy and oncology, Vol. 19, 01.01.1985, p. 82-87.

Research output: Contribution to journalArticle

Jordan, BD, Navia, BA, Petito, C, Cho, ES & Price, RW 1985, 'Neurological syndromes complicating AIDS.', Frontiers of radiation therapy and oncology, vol. 19, pp. 82-87.
Jordan BD, Navia BA, Petito C, Cho ES, Price RW. Neurological syndromes complicating AIDS. Frontiers of radiation therapy and oncology. 1985 Jan 1;19:82-87.
Jordan, B. D. ; Navia, B. A. ; Petito, Carol ; Cho, E. S. ; Price, R. W. / Neurological syndromes complicating AIDS. In: Frontiers of radiation therapy and oncology. 1985 ; Vol. 19. pp. 82-87.
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