Neurological complications of Hepatitis C infection

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Though well-known as a cause of liver disease, Hepatitis C virus infection is emerging as a cause of a variety of peripheral and central nervous system disorders. The virus causes chronic persistent infection with complex immune responses in the majority of individuals. Viral infection may have the potential to generate neurological illness through direct infection of neural cells or through immune-mediated mechanisms, including enhancement of autoimmune responses. Moreover, the mainstay of antiviral treatment of hepatitis C infection, interferon-alpha, is itself associated with neurological morbidity. Thus neurologists are increasingly faced with diagnosing or even predicting a wide spectrum of neurological complications of hepatitis C infection and/or its treatment.

Original languageEnglish
Pages (from-to)642-654
Number of pages13
JournalCurrent Neurology and Neuroscience Reports
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Hepatitis C
Virus Diseases
Infection
Central Nervous System Diseases
Peripheral Nervous System Diseases
Antigen-Antibody Complex
Autoimmunity
Interferon-alpha
Hepacivirus
Antiviral Agents
Liver Diseases
Viruses
Morbidity
Therapeutics

Keywords

  • Central nervous system
  • Cryoglobulinemia
  • Demyelinating neuropathy
  • Encephalitis
  • Hepatitis C
  • Interferon-alpha
  • Myelitis
  • Neuromyelitis optica
  • Peripheral neuropathy
  • Vasculitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neurological complications of Hepatitis C infection. / McCarthy, Micheline; Ortega, Melissa.

In: Current Neurology and Neuroscience Reports, Vol. 12, No. 6, 01.12.2012, p. 642-654.

Research output: Contribution to journalArticle

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