Neurological complications of gliomas

Edward Bass

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter deals with those aspects of glioma management that are not directlyrelated to tumor eradication. The diagnosis of a glioma is not always straightforward.Headaches, seizures and neurocognitive/behavioral changes are common patientcomplaints. Clinical expertise and an understanding of the underlying pathogenesis areneeded. These problems continue to offer challenges at all subsequent stages of gliomamanagement. Factors only indirectly related to the tumor may account for headaches.Hemorrhage into the tumor, hydrocephalus, postoperative complications, radiationdamage, adverse drug reactions and emotional factors merit consideration. Seizuremanagement may also become complex. Treatment controversies include seizureprophylaxis and the merits of various anticonvulsants. Neurocognitive/behavioralproblems may stem from a variety of causes that need to be recognized in order to bestmanage patients. Treatment options are continually evolving. Newer aspects of generegulation important in the pathogenesis of micro-hemorrhages, seizure relatedepileptogenesis, drug resistance and mechanisms of brain edema are altering ourapproach to glioma management. Finally, end of life issues and care-giver support arediscussed.

Original languageEnglish (US)
Title of host publicationGliomas
Subtitle of host publicationSymptoms, Diagnosis and Treatment Options
PublisherNova Science Publishers, Inc.
Number of pages26
ISBN (Print)9781626180895
StatePublished - May 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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