TY - JOUR
T1 - Neurologic Relapse after Benzathine Penicillin Therapy for Secondary Syphilis in a Patient with HIV Infection
AU - Berry, Carol Dawn
AU - Hooton, Thomas M.
AU - Collier, Ann C.
AU - Lukehart, Sheila A.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1987/6/18
Y1 - 1987/6/18
N2 - TREPONEMA pallidum, the etiologic agent of syphilis, may be detected in the cerebrospinal fluid during early infection. The recommended therapeutic agent for primary, secondary, and latent syphilis, benzathine penicillin, does not reach treponemicidal levels within the cerebrospinal fluid, and concerns have been raised that current treatment regimens may be inadequate, particularly in patients who harbor spirochetes in their central nervous systems. We report the failure of benzathine penicillin in the treatment of secondary syphilis in a homosexual man who was seropositive for human immunodeficiency virus (HIV). After therapy, his serum Venereal Disease Research Laboratory (VDRL) test titers decreased appropriately….
AB - TREPONEMA pallidum, the etiologic agent of syphilis, may be detected in the cerebrospinal fluid during early infection. The recommended therapeutic agent for primary, secondary, and latent syphilis, benzathine penicillin, does not reach treponemicidal levels within the cerebrospinal fluid, and concerns have been raised that current treatment regimens may be inadequate, particularly in patients who harbor spirochetes in their central nervous systems. We report the failure of benzathine penicillin in the treatment of secondary syphilis in a homosexual man who was seropositive for human immunodeficiency virus (HIV). After therapy, his serum Venereal Disease Research Laboratory (VDRL) test titers decreased appropriately….
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U2 - 10.1056/NEJM198706183162507
DO - 10.1056/NEJM198706183162507
M3 - Article
C2 - 3587291
AN - SCOPUS:0023202640
VL - 316
SP - 1587
EP - 1589
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 25
ER -