Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome

Joseph R. Berger, Lee Moskowitz, Margaret Fischl, Roger E. Kelley

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Neurologic disease was the harbinger of the acquired immunodeficiency syndrome (AIDS) in 26 (20%) of 132 patients and ultimately developed in 83 (63%). The most common neurologic disorder heralding AIDS was toxoplasmic encephalitis (17 cases) followed by cryptococcal meningitis (six), retinitis (three), progressive multifocal leukoencephalopathy (two), neuropathy (one), myopathy (one), and subacute 'viral' encephalitis (one). In four patients, more than one neurologic disorder coexisted at presentation. Recognition of underlying human T cell lymphotropic virus type III (HTLV-III) infection may allow a more expedient determination of the cause of the neurologic disease. Our study emphasizes the importance of testing for the presence of HTLV-III antibody and assessing the immunologic status of all patients at risk for AIDS who have neurologic illness.

Original languageEnglish (US)
Pages (from-to)683-686
Number of pages4
JournalSouthern medical journal
Issue number6
StatePublished - Jun 1987

ASJC Scopus subject areas

  • Medicine(all)


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