Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS)

Micheline McCarthy, Avindra Nath

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalCurrent Neurology and Neuroscience Reports
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Nervous System
Autoimmune Diseases
HIV Infections
Graft vs Host Disease
Therapeutics
Neurologic Manifestations
Multiple Sclerosis

Keywords

  • AIDS
  • Central nervous system
  • Encephalitis
  • HIV-1
  • Immune deficiency
  • Immune reconstitution
  • Meningitis
  • Opportunistic infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS). / McCarthy, Micheline; Nath, Avindra.

In: Current Neurology and Neuroscience Reports, Vol. 10, No. 6, 01.11.2010, p. 467-475.

Research output: Contribution to journalArticle

@article{2f894a7d4e86478a938e9709579db501,
title = "Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS)",
abstract = "Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes.",
keywords = "AIDS, Central nervous system, Encephalitis, HIV-1, Immune deficiency, Immune reconstitution, Meningitis, Opportunistic infection",
author = "Micheline McCarthy and Avindra Nath",
year = "2010",
month = "11",
day = "1",
doi = "10.1007/s11910-010-0138-y",
language = "English",
volume = "10",
pages = "467--475",
journal = "Current Neurology and Neuroscience Reports",
issn = "1528-4042",
publisher = "Current Medicine Group",
number = "6",

}

TY - JOUR

T1 - Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS)

AU - McCarthy, Micheline

AU - Nath, Avindra

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes.

AB - Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes.

KW - AIDS

KW - Central nervous system

KW - Encephalitis

KW - HIV-1

KW - Immune deficiency

KW - Immune reconstitution

KW - Meningitis

KW - Opportunistic infection

UR - http://www.scopus.com/inward/record.url?scp=78049238099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049238099&partnerID=8YFLogxK

U2 - 10.1007/s11910-010-0138-y

DO - 10.1007/s11910-010-0138-y

M3 - Article

C2 - 20697980

AN - SCOPUS:78049238099

VL - 10

SP - 467

EP - 475

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

SN - 1528-4042

IS - 6

ER -