Neurologic complications following bone marrow transplantation for sickle cell disease

M. R. Abboud, S. M. Jackson, Julio Barredo, K. R. Holden, J. Cure, J. Laver

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A boy with sickle cell anemia underwent bone marrow transplantation (BMT). He was normal on neurological examination, but had radiologic evidence of an old left frontal lobe infarct, multiple cerebral vascular stenoses and moyamoya collaterals. After BMT he developed seizures with extension of the infarct and subarachnoid hemorrhage. One year later angiography revealed worsening stenosis of the M1 segments of both middle cerebral arteries. At that time an increase in von Willebrand's factor with decreased large molecular weight multimers (LvWF) was observed. We speculate that LvWF dependent, shear-induced platelet aggregation, together with endothelial damage may have contributed to the development of neurologic complications in this patient.

Original languageEnglish
Pages (from-to)405-407
Number of pages3
JournalBone Marrow Transplantation
Volume17
Issue number3
StatePublished - Mar 1 1996
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Bone Marrow Transplantation
Nervous System
Pathologic Constriction
Middle Cerebral Artery
Neurologic Examination
von Willebrand Factor
Frontal Lobe
Subarachnoid Hemorrhage
Platelet Aggregation
Blood Vessels
Angiography
Seizures
Molecular Weight

Keywords

  • BMT
  • Neurological problems
  • Sickle cell disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Abboud, M. R., Jackson, S. M., Barredo, J., Holden, K. R., Cure, J., & Laver, J. (1996). Neurologic complications following bone marrow transplantation for sickle cell disease. Bone Marrow Transplantation, 17(3), 405-407.

Neurologic complications following bone marrow transplantation for sickle cell disease. / Abboud, M. R.; Jackson, S. M.; Barredo, Julio; Holden, K. R.; Cure, J.; Laver, J.

In: Bone Marrow Transplantation, Vol. 17, No. 3, 01.03.1996, p. 405-407.

Research output: Contribution to journalArticle

Abboud, MR, Jackson, SM, Barredo, J, Holden, KR, Cure, J & Laver, J 1996, 'Neurologic complications following bone marrow transplantation for sickle cell disease', Bone Marrow Transplantation, vol. 17, no. 3, pp. 405-407.
Abboud, M. R. ; Jackson, S. M. ; Barredo, Julio ; Holden, K. R. ; Cure, J. ; Laver, J. / Neurologic complications following bone marrow transplantation for sickle cell disease. In: Bone Marrow Transplantation. 1996 ; Vol. 17, No. 3. pp. 405-407.
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