Neurologic complications following bone marrow transplantation for sickle cell disease

M. R. Abboud, S. M. Jackson, J. Barredo, K. R. Holden, J. Cure, J. Laver

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A boy with sickle cell anemia underwent bone marrow transplantation (BMT). He was normal on neurological examination, but had radiologic evidence of an old left frontal lobe infarct, multiple cerebral vascular stenoses and moyamoya collaterals. After BMT he developed seizures with extension of the infarct and subarachnoid hemorrhage. One year later angiography revealed worsening stenosis of the M1 segments of both middle cerebral arteries. At that time an increase in von Willebrand's factor with decreased large molecular weight multimers (LvWF) was observed. We speculate that LvWF dependent, shear-induced platelet aggregation, together with endothelial damage may have contributed to the development of neurologic complications in this patient.

Original languageEnglish (US)
Pages (from-to)405-407
Number of pages3
JournalBone Marrow Transplantation
Volume17
Issue number3
StatePublished - Mar 1 1996
Externally publishedYes

Keywords

  • BMT
  • Neurological problems
  • Sickle cell disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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