Neuroleptic malignant syndrome: A complication of neuroleptics and cocaine abuse

Ma Caulay J. Akpaffiong, Pedro Ruiz

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

One hundred and sixty psychiatric patients on Neuroleptics, with and without a history of substance abuse were daily monitored in order to establish the incidence of neuroleptic malignant syndrome in these two groups. Four (5.1%) of the cocaine abusers and none of the non-cocaine abusers developed neuroleptic malignant syndrome when treated with neuroleptics. Thus we argue that psychiatric patients with a history of cocaine abuse may be more at risk of developing neuroleptic malignant syndrome when treated with neuroleptics, possibly associated with the blockade of dopamine (D2-receptors) by neuroleptics and the activation of dopamine/5-HT receptors by cocaine-induced dopamine.

Original languageEnglish (US)
Pages (from-to)299-309
Number of pages11
JournalPsychiatric Quarterly
Volume62
Issue number4
DOIs
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Psychiatry and Mental health

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