Abstract
The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32-39 |
| Number of pages | 8 |
| Journal | Trends in Immunology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2006 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Neuroimmunoendocrine circuitry of the 'brain-skin connection'. / Paus, Ralf; Theoharides, Theoharis C.; Arck, Petra Clara.
In: Trends in Immunology, Vol. 27, No. 1, 01.01.2006, p. 32-39.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neuroimmunoendocrine circuitry of the 'brain-skin connection'
AU - Paus, Ralf
AU - Theoharides, Theoharis C.
AU - Arck, Petra Clara
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
AB - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
UR - http://www.scopus.com/inward/record.url?scp=30544439263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30544439263&partnerID=8YFLogxK
U2 - 10.1016/j.it.2005.10.002
DO - 10.1016/j.it.2005.10.002
M3 - Review article
C2 - 16269267
AN - SCOPUS:30544439263
VL - 27
SP - 32
EP - 39
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -