TY - JOUR
T1 - Neuroimmunoendocrine circuitry of the 'brain-skin connection'
AU - Paus, Ralf
AU - Theoharides, Theoharis C.
AU - Arck, Petra Clara
N1 - Funding Information:
Aspects of our own work was made possible by grants provided by the German Research Foundation to R.P. and P.C.A., as well as a grant from the National Institute of Arthritis, Musculosceletal and Skin Diseases, NIH, USA to T.C.T. We would like to thank J. Christian for her word-processing skills.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/1
Y1 - 2006/1
N2 - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
AB - The skin offers an ideally suited, clinically relevant model for studying the crossroads between peripheral and systemic responses to stress. A 'brain-skin connection' with local neuroimmunoendocrine circuitry underlies the pathogenesis of allergic and inflammatory skin diseases, triggered or aggravated by stress. In stressed mice, corticotropin-releasing hormone, nerve growth factor, neurotensin, substance P and mast cells are recruited hierarchically to induce neurogenic skin inflammation, which inhibits hair growth. The hair follicle is both a target and a source for immunomodulatory stress mediators, and has an equivalent of the hypothalamus-pituitary-adrenal axis. Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention.
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U2 - 10.1016/j.it.2005.10.002
DO - 10.1016/j.it.2005.10.002
M3 - Review article
C2 - 16269267
AN - SCOPUS:30544439263
VL - 27
SP - 32
EP - 39
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -