Neuroimmune interactions in chronic itch of atopic dermatitis

G. Yosipovitch; T. Berger; M. S. Fassett

doi:10.1111/jdv.15973

Neuroimmune interactions in chronic itch of atopic dermatitis

G. Yosipovitch, T. Berger, M. S. Fassett

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Itch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune system and non-histaminergic sensory nerves is responsible for the pathophysiology of chronic itch in atopic dermatitis. An expanding understanding of the contribution of the nervous system and its interaction with immune pathways in atopic itch are helping to identify new therapeutic strategies.

Original language	English (US)
Pages (from-to)	239-250
Number of pages	12
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1111/jdv.15973
State	Published - Feb 1 2020

ASJC Scopus subject areas

Dermatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jdv.15973

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title = "Neuroimmune interactions in chronic itch of atopic dermatitis",

abstract = "Itch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune system and non-histaminergic sensory nerves is responsible for the pathophysiology of chronic itch in atopic dermatitis. An expanding understanding of the contribution of the nervous system and its interaction with immune pathways in atopic itch are helping to identify new therapeutic strategies.",

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AU - Berger, T.

AU - Fassett, M. S.

N1 - Funding Information: Funding sources Medical writing/editorial assistance was provided by Jamie Lim, PhD, of Excerpta Medica and funded by Sanofi Genzyme and Regeneron Pharmaceuticals, Inc. Publisher Copyright: © 2019 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.

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N2 - Itch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune system and non-histaminergic sensory nerves is responsible for the pathophysiology of chronic itch in atopic dermatitis. An expanding understanding of the contribution of the nervous system and its interaction with immune pathways in atopic itch are helping to identify new therapeutic strategies.

AB - Itch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune system and non-histaminergic sensory nerves is responsible for the pathophysiology of chronic itch in atopic dermatitis. An expanding understanding of the contribution of the nervous system and its interaction with immune pathways in atopic itch are helping to identify new therapeutic strategies.

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ER -

Neuroimmune interactions in chronic itch of atopic dermatitis

Abstract

ASJC Scopus subject areas

UN SDGs

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