Neuroimaging of itch as a tool of assessment of chronic itch and its management

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Chronic itch is a multidimensional physical state strongly associated with emotional and cognitive aspects of suffering that causes the urge to scratch. Pathophysiology, psychological stress, and social milieu can influence itch. Here, we review brain neuroimaging research in humans that detects functional and anatomic changes in health and disease states. New data are emerging that are shaping our understanding of itch mechanisms and scratching—the behavioral response as well as the effect of treatments and brain dynamics during itch. Future developments will continue to expand our knowledge of itch mechanisms, allowing translation to clinical assessment and novel therapies focused on the brain, the final relay of itch transmission.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalHandbook of Experimental Pharmacology
StatePublished - Jan 1 2015
Externally publishedYes


  • Claustrum
  • Contagiousitch
  • Craving
  • ESRD
  • Insula
  • Kappa opioids
  • Precuneus

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)


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