Neuroimaging in the evaluation of epilepsy

Naymee J. Velez-Ruiz, Joshua P. Klein

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Neuroimaging has provided extraordinary insight into the pathologic substrate of epilepsy. The excellent spatial resolution and soft tissue contrast of magnetic resonance imaging (MRI) allows identification of a substantial number of pathologies including hippocampal sclerosis, malformations of cortical development, low grade tumors, and vascular abnormalities, among others. Complementary imaging modalities such as positron emission tomography, single photon emission computed tomography, and magnetoencephalography can be diagnostically helpful as well. Identification of a pathologic substrate is particularly important in patients with medically refractory epilepsy who are undergoing evaluation for surgery, and essential in determining the likelihood of seizure freedom after surgical intervention. This article reviews current and emerging neuroimaging techniques in the field of epilepsy.

Original languageEnglish (US)
Pages (from-to)361-373
Number of pages13
JournalSeminars in Neurology
Issue number4
StatePublished - 2012
Externally publishedYes


  • brain tumor
  • cavernous angioma
  • cortical malformation
  • epilepsy
  • hippocampal sclerosis
  • neurocutaneous disorder
  • traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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