Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease

E. J. Mufson, Deborah C Mash, L. B. Hersh

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The cholinergic neurons located within the pedunculopontine nucleus (Ch5) of patients with Alzheimer's disease (AD; n = 15), Parkinson's disease (PD; n = 2), and neurologically normal (n = 6) subjects were visualized immunohistochemically using choline acetyltransferase, pharmacohistochemically using acetylcholinesterase, or by reduced histochemical methods using nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d). Each histochemical procedure localized a well-delineated, compact lateral group and a more diffuse medial group of neurons within the pedunculopontine nucleus. Co-localization experiments revealed that all three enzymes marked the same population of cholingeric neurons. The extent of pathological alterations associated with the cholinergic neurons within the compact lateral sector of the pedunculopontine nucleus was examined in sections that reacted for NADPH-d, counterstained with thioflavin-S. The average number of neurofibrillary tangles within this portion of the pedunculopontine nucleus was 25.4 (range 0-70) in patients with AD, 1.5 (range 1-2) in those with PD, and 1.2 (range 0-4) in aged control subjects. Of the total number of neurofibrillary tangels counted in AD cases, 72.7% were end-stage ghosts and 27.3% were tangle-bearing neurons. The pathological alteration of cholinergic neurons of the compact lateral aspect of the pedunculopontine nucleus may play a role in some of the behavioral features characteristic of AD.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalAnnals of Neurology
Volume24
Issue number5
StatePublished - Jan 1 1988

Fingerprint

Cholinergic Neurons
Alzheimer Disease
NADP
Neurons
Neurofibrillary Tangles
Choline O-Acetyltransferase
Acetylcholinesterase
Parkinson Disease
Enzymes
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mufson, E. J., Mash, D. C., & Hersh, L. B. (1988). Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease. Annals of Neurology, 24(5), 623-629.

Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease. / Mufson, E. J.; Mash, Deborah C; Hersh, L. B.

In: Annals of Neurology, Vol. 24, No. 5, 01.01.1988, p. 623-629.

Research output: Contribution to journalArticle

Mufson, EJ, Mash, DC & Hersh, LB 1988, 'Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease', Annals of Neurology, vol. 24, no. 5, pp. 623-629.
Mufson, E. J. ; Mash, Deborah C ; Hersh, L. B. / Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease. In: Annals of Neurology. 1988 ; Vol. 24, No. 5. pp. 623-629.
@article{674939e0c40a43c097b264258260754b,
title = "Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease",
abstract = "The cholinergic neurons located within the pedunculopontine nucleus (Ch5) of patients with Alzheimer's disease (AD; n = 15), Parkinson's disease (PD; n = 2), and neurologically normal (n = 6) subjects were visualized immunohistochemically using choline acetyltransferase, pharmacohistochemically using acetylcholinesterase, or by reduced histochemical methods using nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d). Each histochemical procedure localized a well-delineated, compact lateral group and a more diffuse medial group of neurons within the pedunculopontine nucleus. Co-localization experiments revealed that all three enzymes marked the same population of cholingeric neurons. The extent of pathological alterations associated with the cholinergic neurons within the compact lateral sector of the pedunculopontine nucleus was examined in sections that reacted for NADPH-d, counterstained with thioflavin-S. The average number of neurofibrillary tangles within this portion of the pedunculopontine nucleus was 25.4 (range 0-70) in patients with AD, 1.5 (range 1-2) in those with PD, and 1.2 (range 0-4) in aged control subjects. Of the total number of neurofibrillary tangels counted in AD cases, 72.7{\%} were end-stage ghosts and 27.3{\%} were tangle-bearing neurons. The pathological alteration of cholinergic neurons of the compact lateral aspect of the pedunculopontine nucleus may play a role in some of the behavioral features characteristic of AD.",
author = "Mufson, {E. J.} and Mash, {Deborah C} and Hersh, {L. B.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "24",
pages = "623--629",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Neurofibrillary tangels in cholinergic penduculopontine neurons in Alzheimer's disease

AU - Mufson, E. J.

AU - Mash, Deborah C

AU - Hersh, L. B.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The cholinergic neurons located within the pedunculopontine nucleus (Ch5) of patients with Alzheimer's disease (AD; n = 15), Parkinson's disease (PD; n = 2), and neurologically normal (n = 6) subjects were visualized immunohistochemically using choline acetyltransferase, pharmacohistochemically using acetylcholinesterase, or by reduced histochemical methods using nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d). Each histochemical procedure localized a well-delineated, compact lateral group and a more diffuse medial group of neurons within the pedunculopontine nucleus. Co-localization experiments revealed that all three enzymes marked the same population of cholingeric neurons. The extent of pathological alterations associated with the cholinergic neurons within the compact lateral sector of the pedunculopontine nucleus was examined in sections that reacted for NADPH-d, counterstained with thioflavin-S. The average number of neurofibrillary tangles within this portion of the pedunculopontine nucleus was 25.4 (range 0-70) in patients with AD, 1.5 (range 1-2) in those with PD, and 1.2 (range 0-4) in aged control subjects. Of the total number of neurofibrillary tangels counted in AD cases, 72.7% were end-stage ghosts and 27.3% were tangle-bearing neurons. The pathological alteration of cholinergic neurons of the compact lateral aspect of the pedunculopontine nucleus may play a role in some of the behavioral features characteristic of AD.

AB - The cholinergic neurons located within the pedunculopontine nucleus (Ch5) of patients with Alzheimer's disease (AD; n = 15), Parkinson's disease (PD; n = 2), and neurologically normal (n = 6) subjects were visualized immunohistochemically using choline acetyltransferase, pharmacohistochemically using acetylcholinesterase, or by reduced histochemical methods using nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d). Each histochemical procedure localized a well-delineated, compact lateral group and a more diffuse medial group of neurons within the pedunculopontine nucleus. Co-localization experiments revealed that all three enzymes marked the same population of cholingeric neurons. The extent of pathological alterations associated with the cholinergic neurons within the compact lateral sector of the pedunculopontine nucleus was examined in sections that reacted for NADPH-d, counterstained with thioflavin-S. The average number of neurofibrillary tangles within this portion of the pedunculopontine nucleus was 25.4 (range 0-70) in patients with AD, 1.5 (range 1-2) in those with PD, and 1.2 (range 0-4) in aged control subjects. Of the total number of neurofibrillary tangels counted in AD cases, 72.7% were end-stage ghosts and 27.3% were tangle-bearing neurons. The pathological alteration of cholinergic neurons of the compact lateral aspect of the pedunculopontine nucleus may play a role in some of the behavioral features characteristic of AD.

UR - http://www.scopus.com/inward/record.url?scp=0023822661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023822661&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 623

EP - 629

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 5

ER -