Neuroendocrine effects of diazepam in panic and generalized anxiety disorders

Peter P. Roy-Byrne, Deborah S. Cowley, Daniel Hommer, James Ritchie, David Greenblatt, Charles Nemeroff

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The adrenocorticotropic hormone (ACTH), cortisol, and growth hormone responses to four consecutive, logarithmically increasing doses of intravenous diazepam compared with placebo given at 15-min intervals were examined in patients with panic disorder (n = 13), generalized anxiety disorder (n = 8), and healthy controls (n = 13). Diazepam caused dose-dependent decreases in cortisol and increases in GH and dose-dependent decreases in ACTH. There were no patient-control differences, possibly due to either the small sample size or the experimental paradigm, which tested subjects in an upright, sitting position in mildly arousing circumstances.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalBiological Psychiatry
Issue number1
StatePublished - Jul 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry


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