The adrenocorticotropic hormone (ACTH), cortisol, and growth hormone responses to four consecutive, logarithmically increasing doses of intravenous diazepam compared with placebo given at 15-min intervals were examined in patients with panic disorder (n = 13), generalized anxiety disorder (n = 8), and healthy controls (n = 13). Diazepam caused dose-dependent decreases in cortisol and increases in GH and dose-dependent decreases in ACTH. There were no patient-control differences, possibly due to either the small sample size or the experimental paradigm, which tested subjects in an upright, sitting position in mildly arousing circumstances.
ASJC Scopus subject areas
- Biological Psychiatry