Neurocognitive changes associated with surgical resection of left and right temporal lobe glioma

Kyle R. Noll, Jeffrey S. Weinberg, Mateo Ziu, Ronald Benveniste, Dima Suki, Jeffrey S. Wefel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BACKGROUND: Little is known regarding the neurocognitive impact of temporal lobe tumor resection. OBJECTIVE: To clarify subacute surgery-related changes in neurocognitive functioning (NCF) in patients with left (LTL) and right (RTL) temporal lobe glioma. METHODS: Patients with glioma in the LTL (n 45) or RTL (n 19) completed comprehensive pre- and postsurgical neuropsychological assessments. NCF was analyzed with 2-way mixed design repeated-measures analysis of variance, with hemisphere (LTL or RTL) as an independent between-subjects factor and pre- and postoperative NCF as a within-subjects factor. RESULTS: About 60% of patients with LTL glioma and 40% with RTL lesions exhibited significant worsening on at least 1 NCF test. Domains most commonly impacted included verbal memory and executive functioning. Patients with LTL tumor showed greater decline than patients with RTL tumor on verbal memory and confrontation naming tests. Nonetheless, over one-third of patients with RTL lesions also showed verbal memory decline. CONCLUSION: In patients with temporal lobe glioma, NCF decline in the subacute postoperative period is common. As expected, patients with LTL tumor show more frequent and severe decline than patients with RTL tumor, particularly on verbally mediated measures. However, a considerable proportion of patients with RTL tumor also exhibit decline across various domains, even those typically associated with left hemisphere structures, such as verbal memory. While patients with RTL lesions may show even greater decline in visuospatial memory, this domain was not assessed. Nonetheless, neuropsychological assessment can identify acquired deficits and help facilitate early intervention in patients with temporal lobe glioma.

Original languageEnglish (US)
Pages (from-to)777-785
Number of pages9
JournalNeurosurgery
Volume77
Issue number5
DOIs
StatePublished - Aug 4 2015

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Temporal Lobe
Glioma
Neoplasms
Postoperative Period
Analysis of Variance

Keywords

  • Brain tumor
  • Cognition
  • Glioma
  • Neurosurgery
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Neurocognitive changes associated with surgical resection of left and right temporal lobe glioma. / Noll, Kyle R.; Weinberg, Jeffrey S.; Ziu, Mateo; Benveniste, Ronald; Suki, Dima; Wefel, Jeffrey S.

In: Neurosurgery, Vol. 77, No. 5, 04.08.2015, p. 777-785.

Research output: Contribution to journalArticle

Noll, Kyle R. ; Weinberg, Jeffrey S. ; Ziu, Mateo ; Benveniste, Ronald ; Suki, Dima ; Wefel, Jeffrey S. / Neurocognitive changes associated with surgical resection of left and right temporal lobe glioma. In: Neurosurgery. 2015 ; Vol. 77, No. 5. pp. 777-785.
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AB - BACKGROUND: Little is known regarding the neurocognitive impact of temporal lobe tumor resection. OBJECTIVE: To clarify subacute surgery-related changes in neurocognitive functioning (NCF) in patients with left (LTL) and right (RTL) temporal lobe glioma. METHODS: Patients with glioma in the LTL (n 45) or RTL (n 19) completed comprehensive pre- and postsurgical neuropsychological assessments. NCF was analyzed with 2-way mixed design repeated-measures analysis of variance, with hemisphere (LTL or RTL) as an independent between-subjects factor and pre- and postoperative NCF as a within-subjects factor. RESULTS: About 60% of patients with LTL glioma and 40% with RTL lesions exhibited significant worsening on at least 1 NCF test. Domains most commonly impacted included verbal memory and executive functioning. Patients with LTL tumor showed greater decline than patients with RTL tumor on verbal memory and confrontation naming tests. Nonetheless, over one-third of patients with RTL lesions also showed verbal memory decline. CONCLUSION: In patients with temporal lobe glioma, NCF decline in the subacute postoperative period is common. As expected, patients with LTL tumor show more frequent and severe decline than patients with RTL tumor, particularly on verbally mediated measures. However, a considerable proportion of patients with RTL tumor also exhibit decline across various domains, even those typically associated with left hemisphere structures, such as verbal memory. While patients with RTL lesions may show even greater decline in visuospatial memory, this domain was not assessed. Nonetheless, neuropsychological assessment can identify acquired deficits and help facilitate early intervention in patients with temporal lobe glioma.

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