Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats

Stephanie L. Collins, Dean Wade, Jennifer Ledon, Sari E Izenwasser

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Chronic treatment with nicotine differentially alters behavior in adolescent rats compared to adult rats. It is not known, however, whether the effects of nicotine on the neurochemical pathways with which it interacts differ in adolescents vs. adults. In the current study, the effects of a 7-day treatment with nicotine on nicotinic, dopaminergic, and serotonergic neurochemistry were examined in the caudate putamen and nucleus accumbens in periadolescent vs. adult male rats. Nicotine treatment increased dopamine transporter densities and decreased serotonin transporter densities in periadolescent rats. There was no change in nicotinic acetylcholine receptor densities or dopamine D1 or D2 receptor densities in nicotine-pretreated periadolescent rats. In adult rats pretreated with nicotine, there was an increase in nicotinic acetylcholine densities, but no change in dopamine transporter, dopamine D1 or D2 receptor, or serotonin transporter densities. Overall, these findings show that periadolescent rats have neurochemical adaptations to nicotine different from adult rats. These alterations may explain, at least in part, the differential behavioral effects of chronic nicotine in adult and adolescent male rats.

Original languageEnglish
Pages (from-to)75-85
Number of pages11
JournalEuropean Journal of Pharmacology
Volume502
Issue number1-2
DOIs
StatePublished - Oct 11 2004

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Nicotine
Dopamine D1 Receptors
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Dopamine D2 Receptors
Neurochemistry
Adolescent Behavior
Caudate Nucleus
Putamen
Nucleus Accumbens
Nicotinic Receptors
Acetylcholine
Therapeutics

Keywords

  • Adolescence
  • Autoradiography
  • Dopamine
  • Nicotine
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats. / Collins, Stephanie L.; Wade, Dean; Ledon, Jennifer; Izenwasser, Sari E.

In: European Journal of Pharmacology, Vol. 502, No. 1-2, 11.10.2004, p. 75-85.

Research output: Contribution to journalArticle

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