Approximately 650 cases of neuroblastoma are diagnosed in the United States each year. With an incidence of 10.2 cases per million, it is the most common cancer that arises during the first year of life and the most common extracranial solid malignancy, representing 8–10% of all pediatric malignancies. Neuroblastoma is also responsible for 15% of childhood cancer mortality (Attiyeh et al. 2005; Brodeur 1997; Maris 2010). The median age at diagnosis is 17 months, and the incidence of the disease quickly dissipates with increasing age (Fig. 5.1).