Abstract
Previous studies have reported hyperactivation of catecholaminergic systems and elevated concentrations of corticotropin-releasing-hormone (CRH) in the cerebrospinal fluid (CSF) of child maltreatment victims or combat veterans with post-traumatic stress disorder (PTSD). This study investigated the CSF concentrations of CRH and monoamine metabolites in rhesus macaque mothers that physically abused their infants and had themselves been abused as infants. Ten abusive mothers and 10 controls served as study subjects. All animals were sampled for CSF during pregnancy and the postpartum period. Focal observations of social and maternal behavior were also made. Abusive mothers had significantly higher CSF concentrations of CRH and 5-HIAA than controls. Across both subjects and controls, higher CRH, 5-HIAA and MHPG concentrations were associated with anti-social behavior patterns including a high frequency of maternal aggression, infant rejection, and a low frequency of contacts received from other individuals. These findings are consistent with those of previous primate and human studies and suggest that the neurobiological alterations associated with infant abuse may play an important role in the occurrence of maladaptive behavior in adulthood, including the perpetuation of infant abuse across generations.
| Original language | English |
|---|---|
| Pages (from-to) | 51-57 |
| Number of pages | 7 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 29 |
| Issue number | 1 SPEC. ISS. |
| DOIs | |
| State | Published - Feb 1 2005 |
| Externally published | Yes |
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Keywords
- Anti-social behavior
- CRH
- Infant abuse
- Monoamine metabolites
- Rhesus macaques
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. / Maestripieri, Dario; Lindell, Stephen G.; Ayala, Alejandro R; Gold, Philip W.; Higley, J. Dee.
In: Neuroscience and Biobehavioral Reviews, Vol. 29, No. 1 SPEC. ISS., 01.02.2005, p. 51-57.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior
AU - Maestripieri, Dario
AU - Lindell, Stephen G.
AU - Ayala, Alejandro R
AU - Gold, Philip W.
AU - Higley, J. Dee
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Previous studies have reported hyperactivation of catecholaminergic systems and elevated concentrations of corticotropin-releasing-hormone (CRH) in the cerebrospinal fluid (CSF) of child maltreatment victims or combat veterans with post-traumatic stress disorder (PTSD). This study investigated the CSF concentrations of CRH and monoamine metabolites in rhesus macaque mothers that physically abused their infants and had themselves been abused as infants. Ten abusive mothers and 10 controls served as study subjects. All animals were sampled for CSF during pregnancy and the postpartum period. Focal observations of social and maternal behavior were also made. Abusive mothers had significantly higher CSF concentrations of CRH and 5-HIAA than controls. Across both subjects and controls, higher CRH, 5-HIAA and MHPG concentrations were associated with anti-social behavior patterns including a high frequency of maternal aggression, infant rejection, and a low frequency of contacts received from other individuals. These findings are consistent with those of previous primate and human studies and suggest that the neurobiological alterations associated with infant abuse may play an important role in the occurrence of maladaptive behavior in adulthood, including the perpetuation of infant abuse across generations.
AB - Previous studies have reported hyperactivation of catecholaminergic systems and elevated concentrations of corticotropin-releasing-hormone (CRH) in the cerebrospinal fluid (CSF) of child maltreatment victims or combat veterans with post-traumatic stress disorder (PTSD). This study investigated the CSF concentrations of CRH and monoamine metabolites in rhesus macaque mothers that physically abused their infants and had themselves been abused as infants. Ten abusive mothers and 10 controls served as study subjects. All animals were sampled for CSF during pregnancy and the postpartum period. Focal observations of social and maternal behavior were also made. Abusive mothers had significantly higher CSF concentrations of CRH and 5-HIAA than controls. Across both subjects and controls, higher CRH, 5-HIAA and MHPG concentrations were associated with anti-social behavior patterns including a high frequency of maternal aggression, infant rejection, and a low frequency of contacts received from other individuals. These findings are consistent with those of previous primate and human studies and suggest that the neurobiological alterations associated with infant abuse may play an important role in the occurrence of maladaptive behavior in adulthood, including the perpetuation of infant abuse across generations.
KW - Anti-social behavior
KW - CRH
KW - Infant abuse
KW - Monoamine metabolites
KW - Rhesus macaques
UR - http://www.scopus.com/inward/record.url?scp=11844252029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11844252029&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2004.05.004
DO - 10.1016/j.neubiorev.2004.05.004
M3 - Article
C2 - 15652254
AN - SCOPUS:11844252029
VL - 29
SP - 51
EP - 57
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
IS - 1 SPEC. ISS.
ER -