Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior

Dario Maestripieri, Stephen G. Lindell, Alejandro R Ayala, Philip W. Gold, J. Dee Higley

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Previous studies have reported hyperactivation of catecholaminergic systems and elevated concentrations of corticotropin-releasing-hormone (CRH) in the cerebrospinal fluid (CSF) of child maltreatment victims or combat veterans with post-traumatic stress disorder (PTSD). This study investigated the CSF concentrations of CRH and monoamine metabolites in rhesus macaque mothers that physically abused their infants and had themselves been abused as infants. Ten abusive mothers and 10 controls served as study subjects. All animals were sampled for CSF during pregnancy and the postpartum period. Focal observations of social and maternal behavior were also made. Abusive mothers had significantly higher CSF concentrations of CRH and 5-HIAA than controls. Across both subjects and controls, higher CRH, 5-HIAA and MHPG concentrations were associated with anti-social behavior patterns including a high frequency of maternal aggression, infant rejection, and a low frequency of contacts received from other individuals. These findings are consistent with those of previous primate and human studies and suggest that the neurobiological alterations associated with infant abuse may play an important role in the occurrence of maladaptive behavior in adulthood, including the perpetuation of infant abuse across generations.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalNeuroscience and Biobehavioral Reviews
Volume29
Issue number1 SPEC. ISS.
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Fingerprint

Maternal Behavior
Social Behavior
Macaca mulatta
Corticotropin-Releasing Hormone
Mothers
Cerebrospinal Fluid
Hydroxyindoleacetic Acid
Methoxyhydroxyphenylglycol
Child Abuse
Veterans
Post-Traumatic Stress Disorders
Aggression
Postpartum Period
Primates
Pregnancy

Keywords

  • Anti-social behavior
  • CRH
  • Infant abuse
  • Monoamine metabolites
  • Rhesus macaques

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. / Maestripieri, Dario; Lindell, Stephen G.; Ayala, Alejandro R; Gold, Philip W.; Higley, J. Dee.

In: Neuroscience and Biobehavioral Reviews, Vol. 29, No. 1 SPEC. ISS., 01.02.2005, p. 51-57.

Research output: Contribution to journalArticle

Maestripieri, Dario ; Lindell, Stephen G. ; Ayala, Alejandro R ; Gold, Philip W. ; Higley, J. Dee. / Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. In: Neuroscience and Biobehavioral Reviews. 2005 ; Vol. 29, No. 1 SPEC. ISS. pp. 51-57.
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