Neurobiologic considerations in early surgery for epilepsy.

M. Duchowny, B. Levin, P. Jayakar, T. J. Resnick

Research output: Contribution to journalArticle

Abstract

Children with well-localized medically resistant seizures are often referred for surgical therapy. In young children, at least three maturational issues play a significant role in the selection process and long-term outcome. First, the early years are a time of exceptionally rapid brain development leading to dynamic changes in the electroencephalogram and the clinical expression of seizures. Many early-onset seizure presentations are also associated with catastrophic outcomes, developmental arrest, or regression. Second, the immature limbic system may be vulnerable to stresses operating in early life, although the consequences may not become apparent for many years. Third, in comparison to the adult, the child's nervous system typically exhibits superior functional recovery after lesioning, but the process of sparing and recovery is often incomplete. An understanding of how these neurobiologic factors influence developmental outcome will ultimately lead to greater selectivity of candidates for early surgery and to improved long-term prognosis.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalJournal of Child Neurology
Volume9 Suppl 2
StatePublished - Oct 1 1994

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Epilepsy
Seizures
Limbic System
Nervous System
Electroencephalography
Brain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Duchowny, M., Levin, B., Jayakar, P., & Resnick, T. J. (1994). Neurobiologic considerations in early surgery for epilepsy. Journal of Child Neurology, 9 Suppl 2, 42-49.

Neurobiologic considerations in early surgery for epilepsy. / Duchowny, M.; Levin, B.; Jayakar, P.; Resnick, T. J.

In: Journal of Child Neurology, Vol. 9 Suppl 2, 01.10.1994, p. 42-49.

Research output: Contribution to journalArticle

Duchowny, M, Levin, B, Jayakar, P & Resnick, TJ 1994, 'Neurobiologic considerations in early surgery for epilepsy.', Journal of Child Neurology, vol. 9 Suppl 2, pp. 42-49.
Duchowny M, Levin B, Jayakar P, Resnick TJ. Neurobiologic considerations in early surgery for epilepsy. Journal of Child Neurology. 1994 Oct 1;9 Suppl 2:42-49.
Duchowny, M. ; Levin, B. ; Jayakar, P. ; Resnick, T. J. / Neurobiologic considerations in early surgery for epilepsy. In: Journal of Child Neurology. 1994 ; Vol. 9 Suppl 2. pp. 42-49.
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