Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants

Bonnie E. Stephens, Jing Liu, Barry Lester, Linda Lagasse, Seetha Shankaran, Henrietta Bada, Charles R Bauer, Abhik Das, Rosemary Higgins

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS). Study design: Data were collected on all preterm infants (<36 weeks) in the MLS who underwent an NNNS at 44 weeks (n = 395) and neurologic examination at 12 to 36 months or Bayley Psychomotor Development Index (PDI) at 24 months (n = 270). Logistic regression analyzed NNNS summary scores associated with cerebral palsy (CP) or PDI <70, while controlling for birth weight ≤1250 g. Results: Eighteen of 395 infants (5%) had CP; 24 of 270 infants (9%) had PDI <70. CP was associated with low quality of movement (odds ratio [OR], 1.95; 95% CI, 1.24-3.06; P = .004) and high lethargy (OR, 1.67; 95% CI, 1.01-2.76; P = .045). The model contributed 19% of the variance in CP diagnosis at 12 to 36 months (R2 = .19, P < .001). Low PDI was associated with low handling (OR, 1.83; 95% CI, 1.12-2.99; P = .017), low quality of movement (OR, 2.16; 95% CI, 1.38-3.38; P = .001), and hypotonia (OR, 1.63; 95% CI, 1.14-2.32; P = .007). The model contributed 26% of the variance in PDI <70 at 24 months (R2 = 0.26, P < .001). Conclusions: The neurobehavioral profile of under-arousal in 44-week-old preterm infants may predict poor motor outcome.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalJournal of Pediatrics
Volume156
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Premature Infants
Cerebral Palsy
Odds Ratio
Life Style
Mothers
Lethargy
Muscle Hypotonia
Neonatal Intensive Care Units
Neurologic Examination
Arousal
Birth Weight
Logistic Models

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Stephens, B. E., Liu, J., Lester, B., Lagasse, L., Shankaran, S., Bada, H., ... Higgins, R. (2010). Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants. Journal of Pediatrics, 156(3), 366-371. https://doi.org/10.1016/j.jpeds.2009.09.042

Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants. / Stephens, Bonnie E.; Liu, Jing; Lester, Barry; Lagasse, Linda; Shankaran, Seetha; Bada, Henrietta; Bauer, Charles R; Das, Abhik; Higgins, Rosemary.

In: Journal of Pediatrics, Vol. 156, No. 3, 01.03.2010, p. 366-371.

Research output: Contribution to journalArticle

Stephens, BE, Liu, J, Lester, B, Lagasse, L, Shankaran, S, Bada, H, Bauer, CR, Das, A & Higgins, R 2010, 'Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants', Journal of Pediatrics, vol. 156, no. 3, pp. 366-371. https://doi.org/10.1016/j.jpeds.2009.09.042
Stephens BE, Liu J, Lester B, Lagasse L, Shankaran S, Bada H et al. Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants. Journal of Pediatrics. 2010 Mar 1;156(3):366-371. https://doi.org/10.1016/j.jpeds.2009.09.042
Stephens, Bonnie E. ; Liu, Jing ; Lester, Barry ; Lagasse, Linda ; Shankaran, Seetha ; Bada, Henrietta ; Bauer, Charles R ; Das, Abhik ; Higgins, Rosemary. / Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants. In: Journal of Pediatrics. 2010 ; Vol. 156, No. 3. pp. 366-371.
@article{8f20fcc0e46b44bebaaea30e4fd35c6a,
title = "Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants",
abstract = "Objective: To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS). Study design: Data were collected on all preterm infants (<36 weeks) in the MLS who underwent an NNNS at 44 weeks (n = 395) and neurologic examination at 12 to 36 months or Bayley Psychomotor Development Index (PDI) at 24 months (n = 270). Logistic regression analyzed NNNS summary scores associated with cerebral palsy (CP) or PDI <70, while controlling for birth weight ≤1250 g. Results: Eighteen of 395 infants (5{\%}) had CP; 24 of 270 infants (9{\%}) had PDI <70. CP was associated with low quality of movement (odds ratio [OR], 1.95; 95{\%} CI, 1.24-3.06; P = .004) and high lethargy (OR, 1.67; 95{\%} CI, 1.01-2.76; P = .045). The model contributed 19{\%} of the variance in CP diagnosis at 12 to 36 months (R2 = .19, P < .001). Low PDI was associated with low handling (OR, 1.83; 95{\%} CI, 1.12-2.99; P = .017), low quality of movement (OR, 2.16; 95{\%} CI, 1.38-3.38; P = .001), and hypotonia (OR, 1.63; 95{\%} CI, 1.14-2.32; P = .007). The model contributed 26{\%} of the variance in PDI <70 at 24 months (R2 = 0.26, P < .001). Conclusions: The neurobehavioral profile of under-arousal in 44-week-old preterm infants may predict poor motor outcome.",
author = "Stephens, {Bonnie E.} and Jing Liu and Barry Lester and Linda Lagasse and Seetha Shankaran and Henrietta Bada and Bauer, {Charles R} and Abhik Das and Rosemary Higgins",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.jpeds.2009.09.042",
language = "English",
volume = "156",
pages = "366--371",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Neurobehavioral Assessment Predicts Motor Outcome in Preterm Infants

AU - Stephens, Bonnie E.

AU - Liu, Jing

AU - Lester, Barry

AU - Lagasse, Linda

AU - Shankaran, Seetha

AU - Bada, Henrietta

AU - Bauer, Charles R

AU - Das, Abhik

AU - Higgins, Rosemary

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Objective: To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS). Study design: Data were collected on all preterm infants (<36 weeks) in the MLS who underwent an NNNS at 44 weeks (n = 395) and neurologic examination at 12 to 36 months or Bayley Psychomotor Development Index (PDI) at 24 months (n = 270). Logistic regression analyzed NNNS summary scores associated with cerebral palsy (CP) or PDI <70, while controlling for birth weight ≤1250 g. Results: Eighteen of 395 infants (5%) had CP; 24 of 270 infants (9%) had PDI <70. CP was associated with low quality of movement (odds ratio [OR], 1.95; 95% CI, 1.24-3.06; P = .004) and high lethargy (OR, 1.67; 95% CI, 1.01-2.76; P = .045). The model contributed 19% of the variance in CP diagnosis at 12 to 36 months (R2 = .19, P < .001). Low PDI was associated with low handling (OR, 1.83; 95% CI, 1.12-2.99; P = .017), low quality of movement (OR, 2.16; 95% CI, 1.38-3.38; P = .001), and hypotonia (OR, 1.63; 95% CI, 1.14-2.32; P = .007). The model contributed 26% of the variance in PDI <70 at 24 months (R2 = 0.26, P < .001). Conclusions: The neurobehavioral profile of under-arousal in 44-week-old preterm infants may predict poor motor outcome.

AB - Objective: To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS). Study design: Data were collected on all preterm infants (<36 weeks) in the MLS who underwent an NNNS at 44 weeks (n = 395) and neurologic examination at 12 to 36 months or Bayley Psychomotor Development Index (PDI) at 24 months (n = 270). Logistic regression analyzed NNNS summary scores associated with cerebral palsy (CP) or PDI <70, while controlling for birth weight ≤1250 g. Results: Eighteen of 395 infants (5%) had CP; 24 of 270 infants (9%) had PDI <70. CP was associated with low quality of movement (odds ratio [OR], 1.95; 95% CI, 1.24-3.06; P = .004) and high lethargy (OR, 1.67; 95% CI, 1.01-2.76; P = .045). The model contributed 19% of the variance in CP diagnosis at 12 to 36 months (R2 = .19, P < .001). Low PDI was associated with low handling (OR, 1.83; 95% CI, 1.12-2.99; P = .017), low quality of movement (OR, 2.16; 95% CI, 1.38-3.38; P = .001), and hypotonia (OR, 1.63; 95% CI, 1.14-2.32; P = .007). The model contributed 26% of the variance in PDI <70 at 24 months (R2 = 0.26, P < .001). Conclusions: The neurobehavioral profile of under-arousal in 44-week-old preterm infants may predict poor motor outcome.

UR - http://www.scopus.com/inward/record.url?scp=76749141261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749141261&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2009.09.042

DO - 10.1016/j.jpeds.2009.09.042

M3 - Article

C2 - 19880137

AN - SCOPUS:76749141261

VL - 156

SP - 366

EP - 371

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 3

ER -