Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas; Charles B. Nemeroff; Arthur J. Prange

doi:10.1016/0014-2999(82)90491-5

Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

Original language	English (US)
Pages (from-to)	471-474
Number of pages	4
Journal	European Journal of Pharmacology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(82)90491-5
State	Published - Mar 26 1982
Externally published	Yes

Keywords

Mesolimbic dopamine system
Neurotensin
Nucleus accumbens
Ventral tegmental area

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(82)90491-5

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title = "Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin",

abstract = "Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).",

keywords = "Mesolimbic dopamine system, Neurotensin, Nucleus accumbens, Ventral tegmental area",

author = "Kalivas, {Peter W.} and Nemeroff, {Charles B.} and Prange, {Arthur J.}",

year = "1982",

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day = "26",

doi = "10.1016/0014-2999(82)90491-5",

language = "English (US)",

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AU - Kalivas, Peter W.

AU - Nemeroff, Charles B.

AU - Prange, Arthur J.

PY - 1982/3/26

Y1 - 1982/3/26

N2 - Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

AB - Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

KW - Mesolimbic dopamine system

KW - Neurotensin

KW - Nucleus accumbens

KW - Ventral tegmental area

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JF - European Journal of Pharmacology

SN - 0014-2999

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ER -

Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Abstract

Keywords

ASJC Scopus subject areas

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