Abstract
Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).
| Original language | English |
|---|---|
| Pages (from-to) | 471-474 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 78 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 26 1982 |
| Externally published | Yes |
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Keywords
- Mesolimbic dopamine system
- Neurotensin
- Nucleus accumbens
- Ventral tegmental area
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin. / Kalivas, Peter W.; Nemeroff, Charles; Prange, Arthur J.
In: European Journal of Pharmacology, Vol. 78, No. 4, 26.03.1982, p. 471-474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin
AU - Kalivas, Peter W.
AU - Nemeroff, Charles
AU - Prange, Arthur J.
PY - 1982/3/26
Y1 - 1982/3/26
N2 - Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).
AB - Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).
KW - Mesolimbic dopamine system
KW - Neurotensin
KW - Nucleus accumbens
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=0020038154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020038154&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(82)90491-5
DO - 10.1016/0014-2999(82)90491-5
M3 - Article
C2 - 7075680
AN - SCOPUS:0020038154
VL - 78
SP - 471
EP - 474
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 4
ER -