Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalEuropean Journal of Pharmacology
Volume78
Issue number4
DOIs
StatePublished - Mar 26 1982
Externally publishedYes

Keywords

  • Mesolimbic dopamine system
  • Neurotensin
  • Nucleus accumbens
  • Ventral tegmental area

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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