Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number4
StatePublished - Mar 26 1982
Externally publishedYes


  • Mesolimbic dopamine system
  • Neurotensin
  • Nucleus accumbens
  • Ventral tegmental area

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


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