Abstract
Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 471-474 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 78 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 26 1982 |
| Externally published | Yes |
Keywords
- Mesolimbic dopamine system
- Neurotensin
- Nucleus accumbens
- Ventral tegmental area
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Kalivas, P. W., Nemeroff, C. B., & Prange, A. J. (1982). Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin. European Journal of Pharmacology, 78(4), 471-474. https://doi.org/10.1016/0014-2999(82)90491-5