Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas; Charles Nemeroff; Arthur J. Prange

doi:10.1016/0014-2999(82)90491-5

Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

Peter W. Kalivas, Charles Nemeroff, Arthur J. Prange

Research output: Contribution to journal › Article

71 Scopus citations

Abstract

Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviours. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 μg/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 μg/side).

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	European Journal of Pharmacology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(82)90491-5
State	Published - Mar 26 1982
Externally published	Yes

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Keywords

Mesolimbic dopamine system
Neurotensin
Nucleus accumbens
Ventral tegmental area

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Cite this

Kalivas, P. W., Nemeroff, C., & Prange, A. J. (1982). Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin. European Journal of Pharmacology, 78(4), 471-474. https://doi.org/10.1016/0014-2999(82)90491-5

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10.1016/0014-2999(82)90491-5