Neurite growth cone-substratum adherence increases in vitro.

R. W. Gundersen, J. N. Barrett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalBrain research
Issue number1
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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