Neurite growth cone-substratum adherence increases in vitro.

R. W. Gundersen, John Barrett

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalBrain Research
Volume314
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Growth Cones
Neurites
Spinal Ganglia
Nerve Growth Factor
Ganglia
Lysine
Collagen
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurite growth cone-substratum adherence increases in vitro. / Gundersen, R. W.; Barrett, John.

In: Brain Research, Vol. 314, No. 1, 01.01.1984, p. 21-26.

Research output: Contribution to journalArticle

Gundersen, R. W. ; Barrett, John. / Neurite growth cone-substratum adherence increases in vitro. In: Brain Research. 1984 ; Vol. 314, No. 1. pp. 21-26.
@article{30bd1017cc364be1bcceaa30ca9e64de,
title = "Neurite growth cone-substratum adherence increases in vitro.",
abstract = "During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.",
author = "Gundersen, {R. W.} and John Barrett",
year = "1984",
month = "1",
day = "1",
language = "English",
volume = "314",
pages = "21--26",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Neurite growth cone-substratum adherence increases in vitro.

AU - Gundersen, R. W.

AU - Barrett, John

PY - 1984/1/1

Y1 - 1984/1/1

N2 - During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.

AB - During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.

UR - http://www.scopus.com/inward/record.url?scp=0021294739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021294739&partnerID=8YFLogxK

M3 - Article

C2 - 6697253

AN - SCOPUS:0021294739

VL - 314

SP - 21

EP - 26

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -