Abstract
During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.
| Original language | English |
|---|---|
| Pages (from-to) | 21-26 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 314 |
| Issue number | 1 |
| State | Published - Jan 1 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neurite growth cone-substratum adherence increases in vitro. / Gundersen, R. W.; Barrett, John.
In: Brain Research, Vol. 314, No. 1, 01.01.1984, p. 21-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurite growth cone-substratum adherence increases in vitro.
AU - Gundersen, R. W.
AU - Barrett, John
PY - 1984/1/1
Y1 - 1984/1/1
N2 - During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.
AB - During experiments characterizing the turning response of dorsal root ganglion neurites toward NGF, it was observed that growth cone-substratum adherance increased with time in culture. The experiments reported here indicate that the observed increase in growth cone-substratum adherance is significant and can be detected with both collagen and poly-L-lysine substrates. The increased adherance is apparently due to a substance(s) produced and released by the ganglia which binds to the substrate, increasing adherance. Flow chamber studies indicate that the substrate-bound substance(s) may be necessary for neurite growth onto artificial tissue culture substrata.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021294739&partnerID=8YFLogxK
M3 - Article
C2 - 6697253
AN - SCOPUS:0021294739
VL - 314
SP - 21
EP - 26
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -