Neural tube defects and associated low birth weight

Shayna M. Norman, Anthony O. Odibo, Ryan E. Longman, Kimberly A. Roehl, George A. MacOnes, Alison G. Cahill

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective To estimate the association between neural tube defects (NTDs) and low birth weight. Study Design This was a retrospective cohort study of women undergoing ultrasound from 17 to 22 weeks from 1990 to 2008. Presence or absence of fetal NTD defined the two study groups. The primary outcomes were intrauterine growth restriction (IUGR), birth weight <10th percentile, and severe IUGR <5th percentile. Subgroup analysis was performed to observe if the association with IUGR persisted. Results Of 66,956 women, 170 were found to have fetal NTD. Only the rate of advanced maternal age differed between the study groups. Fetuses with an NTD were at significantly increased risk for IUGR <10th percentile (adjusted odds ratio [aOR] 2.6, 95% confidence interval [CI] 1.8 to 3.9) and <5th percentile (aOR 2.8, 95% CI 1.9 to 4.3). The association persisted in subgroup analyses. Conclusion Fetuses with NTD are at increased risk for IUGR, suggesting that a policy of serial growth scans in cases with isolated NTD is justified.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalAmerican Journal of Perinatology
Volume29
Issue number6
DOIs
StatePublished - Mar 8 2012
Externally publishedYes

Keywords

  • growth restriction
  • low birth weight
  • neural tube defect
  • ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Neural tube defects and associated low birth weight'. Together they form a unique fingerprint.

  • Cite this

    Norman, S. M., Odibo, A. O., Longman, R. E., Roehl, K. A., MacOnes, G. A., & Cahill, A. G. (2012). Neural tube defects and associated low birth weight. American Journal of Perinatology, 29(6), 473-476. https://doi.org/10.1055/s-0032-1304830