Neural correlates of inhibitory deficits in depression

Fanny Eugène, Jutta Joormann, Rebecca E. Cooney, Lauren Y. Atlas, Ian H. Gotlib

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


The present study used functional magnetic resonance imaging to examine neural correlates of inhibitory dysfunction in individuals diagnosed with major depressive disorder (MDD). Twelve MDD participants and 12 never-depressed controls completed the negative affective priming (NAP) task in the scanner. Results indicated that, in depressed participants, increased activation in the rostral anterior cingulate cortex (rACC) is associated with inhibition of negative, but not positive, words; in contrast, in nondepressed participants, inhibition of positive, but not negative, words is associated with increased activation in the rACC. These findings indicate that abnormalities in neural function, especially in the rACC, may underlie difficulties experienced by depressed individuals in inhibiting negative thoughts. These results underscore the importance of continuing to examine the relation between cognitive and neural functioning in depression in order to gain a broader and more integrative understanding of this disorder.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalPsychiatry Research - Neuroimaging
Issue number1
StatePublished - Jan 30 2010
Externally publishedYes


  • Anterior cingulate cortex
  • Functional magnetic resonance imaging
  • Inhibition
  • Negative priming

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)


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