Neural cell adhesion molecule L1: Signaling pathways and growth cone motility

Hiroyuki Kamiguchi, Vance Lemmon

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

The neural cell adhesion molecule L1 plays a key role in nervous system development including neuronal migration, neurite growth, and axonal fasciculation. L1 is expressed on most developing axons, and homophilic binding of L1 molecules on adjacent axons is likely to play a key role in axon extension. It is now well documented that a number of second-messenger systems are involved in L1-stimulated neurite growth in vitro. However, it is unclear how L1 homophilic or heterophilic binding trigger signals that regulate the mechanical forces that produce axon extension. In this report, we will review recent advances in understanding L1-associated signals, L1 interactions with the cytoskeleton, and the molecular mechanisms underlying growth cone motility.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Neuroscience Research
Volume49
Issue number1
DOIs
StatePublished - Jul 1 1997
Externally publishedYes

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Keywords

  • Immunoglobulin superfamily
  • Neurite outgrowth
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)

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