Neural activity in frontal cortical cell layers

Evidence for columnar sensorimotor processing

Ioan Opris, Robert E. Hampson, Terrence R. Stanford, Greg A. Gerhardt, Sam A. Deadwyler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The mammalian frontal cortex (FCx) is at the top of the brain's sensorimotor hierarchy and includes cells in the supragranular Layer 2/3, which integrate convergent sensory information for transmission to infragranular Layer 5 cells to formulate motor system outputs that control behavioral responses. Functional interaction between these two layers of FCx was examined using custom-designed ceramic-based microelectrode arrays (MEAs) that allowed simultaneous recording of firing patterns of FCx neurons in Layer 2/3 and Layer 5 in nonhuman primates performing a simple go/no-go discrimination task. This unique recording arrangement showed differential encoding of task-related sensory events by cells in each layer with Layer 2/3 cells exhibiting larger firing peaks during presentation of go target and no-go target task images, whereas Layer 5 cells showed more activity during reward contingent motor responses in the task. Firing specificity to task-related events was further demonstrated by synchronized firing between pairs of cells in different layers that occupied the same vertically oriented "column" on the MEA. Pairs of cells in different layers recorded at adjacent "noncolumnar" orientations on the MEA did not show synchronized firing during the same task-related events. The results provide required evidence in support of previously suggested task-related sensorimotor processing in the FCx via functionally segregated minicolumns.

Original languageEnglish (US)
Pages (from-to)1507-1521
Number of pages15
JournalJournal of Cognitive Neuroscience
Volume23
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

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Frontal Lobe
Microelectrodes
Ceramics
Reward
Primates
Neurons
Brain

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Neural activity in frontal cortical cell layers : Evidence for columnar sensorimotor processing. / Opris, Ioan; Hampson, Robert E.; Stanford, Terrence R.; Gerhardt, Greg A.; Deadwyler, Sam A.

In: Journal of Cognitive Neuroscience, Vol. 23, No. 6, 01.06.2011, p. 1507-1521.

Research output: Contribution to journalArticle

Opris, Ioan ; Hampson, Robert E. ; Stanford, Terrence R. ; Gerhardt, Greg A. ; Deadwyler, Sam A. / Neural activity in frontal cortical cell layers : Evidence for columnar sensorimotor processing. In: Journal of Cognitive Neuroscience. 2011 ; Vol. 23, No. 6. pp. 1507-1521.
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